Antibiotics are of environmental concern. Their concentrations in the aquatic environment are frequently studied, while their occurrence in human excreta-derived fertilizers is less investigated. Therefore, levels of antibiotics, preservatives with antimicrobial properties, and various other micropollutants were determined in sewage sludge and in human fecal compost. Digested sludge of 29 Swiss wastewater treatment plants was analyzed, representing about 2.6 Mio people (30% of the Swiss population). This was compared with residues found in compost with dry toilet content after thermophilic composting, representing about 10 000 people. Fluoroquinolones and preservatives dominate in Swiss sewage sludge with weighted mean concentrations of 6500 μg kg⁻¹ and 2300 μg kg⁻¹. Levels of macrolides (240 μg kg⁻¹), β-lactam transformation products (35 μg kg⁻¹) and sulfonamides (15 μg kg⁻¹) were lower. Pollution patterns in digested sewage sludge were relatively constant throughout Switzerland. Levels of contamination in fecal compost were approximately 30 times lower than in sewage sludge. Pollution patterns differed between compost and sludge. Chemicals used in down-the-drain-applications (e.g., preservatives from personal care products or corrosion inhibitors) are less relevant in compost. Based on the Swiss consumption and excretion data, a mass flow analysis was carried out for antibiotics and pharmaceuticals in sludge and compost. The mass flow analysis in sludge showed a good agreement of predicted and measured concentrations for compounds that tend to sorb to organic matter (e.g., fluoroquinolones). Currently, there is no specific legislation that regulates the use of fecal compost from dry toilets as fertilizer. However, the one to two order of magnitude lower levels of contaminants in fecal compost compared to sludge and manure indicate a lower environmental risk when applying it as fertilizer.