As municipal wastewater treatment regulations become more stringent, integrating source-separated urine treatment into centralized urban wastewater management offers a ‘hybrid’ solution. However, it is not clear how the environmental impacts of such hybrid systems compare to highly efficient centralized wastewater treatment plants (WWTPs) with low N₂O emissions and electricity use. In this study, a consequential life cycle assessment was used to compare the environmental impact of three urine separation hybrid wastewater treatment systems – which combine decentralized urine treatment with a highly efficient central WWTP– to a centralized WWTP treating mixed wastewater (baseline). The studied urine treatment systems include partial nitrification & distillation, struvite precipitation & stripping/scrubbing, and partial nitritation/anammox. Additionally, the environmental impact of urine pre-treatment by calcium hydroxide and electrochemical alkalinization methods on the partial nitrification & distillation system was evaluated. The results show that all hybrid scenarios have a lower environmental impact in the freshwater ecotoxicity, marine toxicity, freshwater eutrophication, and marine eutrophication categories compared to the baseline. However, all hybrid scenarios resulted in higher impacts on global warming compared to the baseline, with direct N₂O emissions being a key variable. Additionally, it was identified that urine alkalinization increased the environmental impact of the treatment system in 7 out of the 10 impact categories. A Pareto frontier analysis was developed to guide decision makers on where hybrid solutions could be used as a strategy to reduce the global warming impacts of conventional WWTPs. Using N₂O-N emission factors of 75 WWTPs, 87 % of centralized WWTPs had a lower global warming impact compared to partial nitrification & distillation, and 91 % compared to partial nitritation/anammox hybrid solutions. However, at electricity demands of 1 kWh/PE/day and 1.5 kWh/PE/day at the central WWTP, both hybrid solutions showed lower global warming impact than all the studied WWTPs. The study highlights the potential of hybrid wastewater treatment solutions as a strategy to reduce global warming impacts in WWTPs with high N₂O emissions and electricity use as well as a means to reduce marine eutrophication (i.e. nitrogen pollution).