This paper proposes a framework for the analysis of technological innovation processes in transnational contexts. By drawing on existing innovation system concepts and recent elaborations on the globalization of innovation, we develop a multi-scalar conceptualization of innovation systems. Two key mechanisms are introduced and elaborated: the generation of resources in multi-locational subsystems and the establishment of structural couplings among them in a global innovation system (GIS). Based on this conceptualization, we introduce a typology of four generic GIS configurations, building on the innovation mode and valuation system in different industry types. The analytical framework is illustrated with insights from four emerging clean-tech industries. We state that a comprehensive GIS perspective is instrumental for developing a more explanatory stance in the innovation system literature and developing policy interventions that reflect the increasing spatial complexity in the innovation process.