Standing at a crossroads, where ongoing 'slowbalisation' coincides with new forces such as the outbreak of the Covid-19 pandemic, heightened geopolitical tensions, the emergence of disruptive technologies and the increasing urgency of addressing environmental challenges, many important questions remain unsolved regarding the nature and impact of the current economic globalisation. This special issue on 'Globalisation in Reverse? Reconfiguring the Geographies of Value Chains and Production Networks' aims at showcasing recent work that seeks to contribute to, and advance, the debates on economic globalisation and the reconfiguration of global value chains and production networks. This introductory article has three objectives: first, based on a broad literature review, we aim to identify four key forces, as well as the fundamental relatively stable capitalist logics contributing to the complex reconfiguration of global economic activities. Second, we will position the papers included in this special issue against the four main forces identified and discuss the contributions of each article to capture some emerging cross-paper patterns among them. Finally, we outline the contours of a research agenda that suggests promising avenues for further investigation of the phenomenon of value chain and production network reconfigurations in times of uncertainty.