Endocrine disrupting compounds affecting corticosteroid signaling pathways in Czech and Swiss waters: potential impact on fish

Macikova P, Groh KJ, Ammann AA, Schirmer K & Suter MJ-F
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Macikova, P., Groh, K. J., Ammann, A. A., Schirmer, K., & Suter, M. J. F. (2014). Endocrine disrupting compounds affecting corticosteroid signaling pathways in Czech and Swiss waters: potential impact on fish. Environmental Science and Technology, 48(21), 12902-12911. https://doi.org/10.1021/es502711c
https://www.dora.lib4ri.ch/eawag/islandora/object/eawag:7829

This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 μg/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from

Details
Publication Type

Journal Article

Title

Endocrine disrupting compounds affecting corticosteroid signaling pathways in Czech and Swiss waters: potential impact on fish

Author(s)

Macikova, Petra

Groh, Ksenia J. (Environmental Toxicology UTOX)

Ammann, Adrian A. (Environmental Toxicology UTOX)

Schirmer, Kristin (Environmental Toxicology UTOX)

Suter, Marc J.-F. (Environmental Toxicology UTOX)

Journal

Environmental Science and Technology

Volume

48

Issue

21

Start Page

12902

End Page

12911

Publication Year

2014

Peer Review

Yes