A method is described for the simultaneous determination of Hydrochlorothiazide (HCTZ), Amlodipine besylate (AML), Telmisartan (TELM) and Valsartan (VAL) using gradient elution by HPLC-UV detection. The separation was carried out on a 150 x 4.6mm i.d. Zorbax C₁₈, 5 μm column with mobile phase A, containing 10 mM potassium dihydrogen phosphate and 10 mM butane sulphonic acid with 0.4% triethylamine (pH 3.0), ortho phosphoric acid and ammonia. Mobile phase-B composed of acetonitrile using gradient elution at a flow rate of 1 mLmin-1 was used. The calibration curve was linear for Hydrochlorothiazide having concentration range (0.1-6.0) μgmL^-1, Amlodipine (0.25-10.0) μgmL^-1, Telmisartan (0.05-4.0) μgmL^-1, and Valsartan (0.05-4.0) μgmL^-1. Various parameters like precision, accuracy, limit of detection, limit of quantitation, robustness, ruggedness and solution stability of method were checked for validation. We have successfully developed short gradient run time; this is the main advantage of our research work. In addition to this, we have recovered four drugs simultaneously in human plasma using this short gradient method. The developed method was applied to determine these components from human plasma.