Targeted synthesis of complex spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by intramolecular cyclization of azomethine ylides: highly potent MDM2-p53 inhibitors

Gollner A, Weinstabl H, Fuchs JE, Rudolph D, Garavel G, Hofbauer KS, Karolyi-Oezguer J, Gmaschitz G, Hela W, Kerres N, Grondal E, Werni P, Ramharter J, Broeker J & McConnell DB
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Gollner, A., Weinstabl, H., Fuchs, J. E., Rudolph, D., Garavel, G., Hofbauer, K. S., … McConnell, D. B. (2019). Targeted synthesis of complex spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by intramolecular cyclization of azomethine ylides: highly potent MDM2-p53 inhibitors. ChemMedChem, 14(1), 88-93. https://doi.org/10.1002/cmdc.201800617