Discovery of N-substituted 3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acids as highly potent third-generation inhibitors of human arginase I and II

Van Zandt MC, Jagdmann GE, Whitehouse DL, Ji M, Savoy J, Potapova O, Cousido-Siah A, Mitschler A, Howard EI, Pyle AM & Podjarny AD
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Van Zandt, M. C., Jagdmann, G. E., Whitehouse, D. L., Ji, M., Savoy, J., Potapova, O., … Podjarny, A. D. (2019). Discovery of N-substituted 3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acids as highly potent third-generation inhibitors of human arginase I and II. Journal of Medicinal Chemistry, 62(17), 8164-8177. https://doi.org/10.1021/acs.jmedchem.9b00931