Discovery and optimization of 2-Arylquinazolin-4-ones into a potent and selective tankyrase inhibitor modulating Wnt pathway activity

Buchstaller H-P, Anlauf U, Dorsch D, Kuhn D, Lehmann M, Leuthner B, Musil D, Radtki D, Ritzert C, Rohdich F, Schneider R & Esdar C
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Buchstaller, H. P., Anlauf, U., Dorsch, D., Kuhn, D., Lehmann, M., Leuthner, B., … Esdar, C. (2019). Discovery and optimization of 2-Arylquinazolin-4-ones into a potent and selective tankyrase inhibitor modulating Wnt pathway activity. Journal of Medicinal Chemistry, 62(17), 7897-7909. https://doi.org/10.1021/acs.jmedchem.9b00656