Emergence of a negative activation heat capacity during evolution of a designed enzyme

Bunzel HA, Kries H, Marchetti L, Zeymer C, Mittl PRE, Mulholland AJ & Hilvert D
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Bunzel, H. A., Kries, H., Marchetti, L., Zeymer, C., Mittl, P. R. E., Mulholland, A. J., & Hilvert, D. (2019). Emergence of a negative activation heat capacity during evolution of a designed enzyme. Journal of the American Chemical Society, 141(30), 11745-11748. https://doi.org/10.1021/jacs.9b02731