Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors

Zhou H, McGowan MA, Lipford K, Christopher M, Fradera X, Witter D, Lesburg CA, Li C, Methot JL, Lampe J, Achab A, Shaffer L, Goldenblatt P, Shah S, Bass A, Schroeder G, Chen D, Zeng H, Augustin MA & Katz JD
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Zhou, H., McGowan, M. A., Lipford, K., Christopher, M., Fradera, X., Witter, D., … Katz, J. D. (2020). Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors. Bioorganic and Medicinal Chemistry Letters, 30(1), 126715 (8 pp.). https://doi.org/10.1016/j.bmcl.2019.126715