Design and evaluation of highly selective human immunoproteasome inhibitors reveal a compensatory process that preserves immune cell viability

Ladi E, Everett C, Stivala CE, Daniels BE, Durk MR, Harris SF, Huestis MP, Purkey HE, Staben ST, Augustin M, Blaesse M, Steinbacher S, Eidenschenk C, Pappu R & Siu M
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Ladi, E., Everett, C., Stivala, C. E., Daniels, B. E., Durk, M. R., Harris, S. F., … Siu, M. (2019). Design and evaluation of highly selective human immunoproteasome inhibitors reveal a compensatory process that preserves immune cell viability. Journal of Medicinal Chemistry, 62(15), 7032-7041. https://doi.org/10.1021/acs.jmedchem.9b00509