Identification of CNS-penetrant aryl sulfonamides as isoform-selective NaV1.6 inhibitors with efficacy in mouse models of epilepsy

Focken T, Burford K, Grimwood ME, Zenova A, Andrez J-C, Gong W, Wilson M, Taron M, Decker S, Lofstrand V, Chowdhury S, Shuart N, Lin S, Goodchild SJ, Young C, Soriano M, Tari PK, Waldbrook M, Nelkenbrecher K, Kwan R, Lindgren A, de Boer G, Lee S, Sojo L, DeVita RJ, Cohen CJ, Wesolowski SS, Johnson, Jr. JP, Dehnhardt CM & Empfield JR
Choose the citation style.
Focken, T., Burford, K., Grimwood, M. E., Zenova, A., Andrez, J. C., Gong, W., … Empfield, J. R. (2019). Identification of CNS-penetrant aryl sulfonamides as isoform-selective NaV1.6 inhibitors with efficacy in mouse models of epilepsy. Journal of Medicinal Chemistry, 62(21), 9618-9641. https://doi.org/10.1021/acs.jmedchem.9b01032