Rational design and optimization of a novel class of macrocyclic apoptosis signal-regulating kinase 1 inhibitors

Himmelbauer MK, Xin Z, Jones JH, Enyedy I, King K, Marcotte DJ, Murugan P, Santoro JC, Hesson T, Spilker K, Johnson JL, Luzzio MJ, Gilfillan R & Gonzalez-Lopez de Turiso F
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Himmelbauer, M. K., Xin, Z., Jones, J. H., Enyedy, I., King, K., Marcotte, D. J., … Gonzalez-Lopez de Turiso, F. (2019). Rational design and optimization of a novel class of macrocyclic apoptosis signal-regulating kinase 1 inhibitors. Journal of Medicinal Chemistry, 62(23), 10740-10756. https://doi.org/10.1021/acs.jmedchem.9b01206