Discovery of potent, selective, and orally bioavailable inhibitors of USP7 with in vivo antitumor activity

Leger PR, Hu DX, Biannic B, Bui M, Han X, Karbarz E, Maung J, Okano A, Osipov M, Shibuya GM, Young K, Higgs C, Abraham B, Bradford D, Cho C, Colas C, Jacobson S, Ohol YM, Pookot D, Rana P, Sanchez J, Shah N, Sun M, Wong S, Brockstedt DG, Kassner PD, Schwarz JB & Wustrow DJ
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Leger, P. R., Hu, D. X., Biannic, B., Bui, M., Han, X., Karbarz, E., … Wustrow, D. J. (2020). Discovery of potent, selective, and orally bioavailable inhibitors of USP7 with in vivo antitumor activity. Journal of Medicinal Chemistry, 63(10), 5398-5420. https://doi.org/10.1021/acs.jmedchem.0c00245