Discovery of N-(4-Aminobutyl)-N′-(2-methoxyethyl)guanidine as the first selective, nonamino acid, catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1)

Lunk I, Litty FA, Hennig S, Vetter IR, Kotthaus J, Altmann KS, Ott G, Havemeyer A, Garciá CC, Clement B & Schade D
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Lunk, I., Litty, F. A., Hennig, S., Vetter, I. R., Kotthaus, J., Altmann, K. S., … Schade, D. (2020). Discovery of N-(4-Aminobutyl)-N′-(2-methoxyethyl)guanidine as the first selective, nonamino acid, catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1). Journal of Medicinal Chemistry, 63(1), 425-432. https://doi.org/10.1021/acs.jmedchem.9b01230