Discovery of CNS-penetrant apoptosis signal-regulating kinase 1 (ASK1) inhibitors

Xin Z, Himmelbauer MK, Jones JH, Enyedy I, Gilfillan R, Hesson T, King K, Marcotte DJ, Murugan P, Santoro JC & Gonzalez-Lopez De Turiso F
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Xin, Z., Himmelbauer, M. K., Jones, J. H., Enyedy, I., Gilfillan, R., Hesson, T., … Gonzalez-Lopez De Turiso, F. (2020). Discovery of CNS-penetrant apoptosis signal-regulating kinase 1 (ASK1) inhibitors. ACS Medicinal Chemistry Letters, 11(4), 485-490. https://doi.org/10.1021/acsmedchemlett.9b00611