Discovery of 3-pyridyl isoindolin-1-one derivatives as potent, selective, and orally active aldosterone synthase (CYP11B2) inhibitors

Liu Y, Wu J, Zhou M, Chen W, Li D, Wang Z, Hornsperger B, Aebi JD, Märki H-P, Kuhn B, Wang L, Kuglstatter A, Benz J, Müller S, Hochstrasser R, Ottaviani G, Xin J, Kirchner S, Mohr S, Verry P, Riboulet W, Shen HC, Mayweg AV, Amrein K & Tan X
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Liu, Y., Wu, J., Zhou, M., Chen, W., Li, D., Wang, Z., … Tan, X. (2020). Discovery of 3-pyridyl isoindolin-1-one derivatives as potent, selective, and orally active aldosterone synthase (CYP11B2) inhibitors. Journal of Medicinal Chemistry, 63(13), 6876-6897. https://doi.org/10.1021/acs.jmedchem.0c00233