Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors

Hu Z, Wang C, Sitkoff D, Cheadle NL, Xu S, Muckelbauer JK, Adam LP, Wexler RR & Quan ML
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Hu, Z., Wang, C., Sitkoff, D., Cheadle, N. L., Xu, S., Muckelbauer, J. K., … Quan, M. L. (2020). Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors. Bioorganic and Medicinal Chemistry Letters, 30(21), 127474 (6 pp.). https://doi.org/10.1016/j.bmcl.2020.127474