Discovery of BIIB068: a selective, potent, reversible Bruton's tyrosine kinase inhibitor as an orally efficacious agent for autoimmune diseases

Ma B, Bohnert T, Otipoby KL, Tien E, Arefayene M, Bai J, Bajrami B, Bame E, Chan TR, Humora M, MacPhee JM, Marcotte D, Mehta D, Metrick CM, Moniz G, Polack E, Poreci U, Prefontaine A, Sheikh S, Schroeder P, Smirnakis K, Zhang L, Zheng F & Hopkins BT
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Ma, B., Bohnert, T., Otipoby, K. L., Tien, E., Arefayene, M., Bai, J., … Hopkins, B. T. (2020). Discovery of BIIB068: a selective, potent, reversible Bruton's tyrosine kinase inhibitor as an orally efficacious agent for autoimmune diseases. Journal of Medicinal Chemistry, 63(21), 12526-12541. https://doi.org/10.1021/acs.jmedchem.0c00702