Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

Ferri E, Le Thomas A, Ackerly Wallweber H, Day ES, Walters BT, Kaufman SE, Braun M-G, Clark KR, Beresini MH, Mortara K, Chen Y-CA, Canter B, Phung W, Liu PS, Lammens A, Ashkenazi A, Rudolph J & Wang W
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Ferri, E., Le Thomas, A., Ackerly Wallweber, H., Day, E. S., Walters, B. T., Kaufman, S. E., … Wang, W. (2020). Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands. Nature Communications, 11(1), 6387 (15 pp.). https://doi.org/10.1038/s41467-020-19974-5