Dual epitope targeting and enhanced hexamerization by DR5 antibodies as a novel approach to induce potent antitumor activity through DR5 agonism

Overdijk MB, Strumane K, Beurskens FJ, Ortiz Buijsse A, Vermot-Desroches C, Vuillermoz BS, Kroes T, de Jong B, Hoevenaars N, Hibbert RG, Lingnau A, Forssmann U, Schuurman J, Parren PWHI, de Jong RN & Breij ECW
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Overdijk, M. B., Strumane, K., Beurskens, F. J., Ortiz Buijsse, A., Vermot-Desroches, C., Vuillermoz, B. S., … Breij, E. C. W. (2020). Dual epitope targeting and enhanced hexamerization by DR5 antibodies as a novel approach to induce potent antitumor activity through DR5 agonism. Molecular Cancer Therapeutics, 19(10), 2126-2138. https://doi.org/10.1158/1535-7163.MCT-20-0044