Discovery of protein-protein interaction inhibitors by integrating protein engineering and chemical screening platforms

Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M & Dikic I
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Maculins, T., Garcia-Pardo, J., Skenderovic, A., Gebel, J., Putyrski, M., Vorobyov, A., … Dikic, I. (2020). Discovery of protein-protein interaction inhibitors by integrating protein engineering and chemical screening platforms. Cell Chemical Biology, 27(11), 1441-1451.e7. https://doi.org/10.1016/j.chembiol.2020.07.010