Discovery of diaminopyrimidine carboxamide HPK1 inhibitors as preclinical immunotherapy tool compounds

Vara BA, Levi SM, Achab A, Candito DA, Fradera X, Lesburg CA, Kawamura S, Lacey BM, Lim J, Methot JL, Xu Z, Xu H, Smith DM, Piesvaux JA, Miller JR, Bittinger M, Ranganath SH, Bennett DJ, DiMauro EF & Pasternak A
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Vara, B. A., Levi, S. M., Achab, A., Candito, D. A., Fradera, X., Lesburg, C. A., … Pasternak, A. (2021). Discovery of diaminopyrimidine carboxamide HPK1 inhibitors as preclinical immunotherapy tool compounds. ACS Medicinal Chemistry Letters, 12(4), 653-661. https://doi.org/10.1021/acsmedchemlett.1c00096