Projected dose optimization of amino- and hydroxypyrrolidine purine PI3Kδ immunomodulators

Methot JL, Zhou H, McGowan MA, Anthony NJ, Christopher M, Garcia Y, Achab A, Lipford K, Wesley Trotter B, Altman MD, Fradera X, Lesburg CA, Li C, Alves S, Chappell CP, Jain R, Mangado R, Pinheiro E, Williams SMG, Goldenblatt P, Hill A, Shaffer L, Chen D, Tong V, McLeod RL, Lee H-H, Yu H, Shah S & Katz JD
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Methot, J. L., Zhou, H., McGowan, M. A., Anthony, N. J., Christopher, M., Garcia, Y., … Katz, J. D. (2021). Projected dose optimization of amino- and hydroxypyrrolidine purine PI3Kδ immunomodulators. Journal of Medicinal Chemistry, 64(8), 5137-5156. https://doi.org/10.1021/acs.jmedchem.1c00237