Synthesis of the potent, selective, and efficacious β-secretase (BACE1) inhibitor NB-360

Rueeger H, Lueoend R, Machauer R, Veenstra SJ, Holzer P, Hurth K, Voegtle M, Frederiksen M, Rondeau J-M, Tintelnot-Blomley M, Jacobson LH, Staufenbiel M, Laue G & Neumann U
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Rueeger, H., Lueoend, R., Machauer, R., Veenstra, S. J., Holzer, P., Hurth, K., … Neumann, U. (2021). Synthesis of the potent, selective, and efficacious β-secretase (BACE1) inhibitor NB-360. Journal of Medicinal Chemistry, 64(8), 4677-4696. https://doi.org/10.1021/acs.jmedchem.0c02143