Design, synthesis, and evaluation of a novel series of indole sulfonamide peroxisome proliferator activated receptor (PPAR) α/γ/δ triple activators: discovery of lanifibranor, a new antifibrot

Boubia B, Poupardin O, Barth M, Binet J, Peralba P, Mounier L, Jacquier E, Gauthier E, Lepais V, Chatar M, Ferry S, Thourigny A, Guillier F, Llacer J, Amaudrut J, Dodey P, Lacombe O, Masson P, Montalbetti C, Wettstein G, Luccarini J-M, Legendre C, Junien J-L & Broqua P
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Boubia, B., Poupardin, O., Barth, M., Binet, J., Peralba, P., Mounier, L., … Broqua, P. (2018). Design, synthesis, and evaluation of a novel series of indole sulfonamide peroxisome proliferator activated receptor (PPAR) α/γ/δ triple activators: discovery of lanifibranor, a new antifibrotic clinical candidate. Journal of Medicinal Chemistry, 61(6), 2246-2265. https://doi.org/10.1021/acs.jmedchem.7b01285