Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk

Caldwell R, Liu-Bujalski L, Qiu H, Mochalkin I, Jones R, Neagu C, Goutopoulos A, Grenningloh R, Johnson T, Sherer B, Gardberg A, Follis AV, Morandi F & Head J
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Caldwell, R., Liu-Bujalski, L., Qiu, H., Mochalkin, I., Jones, R., Neagu, C., … Head, J. (2018). Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk. Bioorganic and Medicinal Chemistry Letters, 28(21), 3419-3424. https://doi.org/10.1016/j.bmcl.2018.09.033