Electrifying the global economy is accepted as a main decarbonization lever to reach the Paris Agreement targets. The IEA’s 2050 Net Zero transition pathways all involve some degree of nuclear power, highlighting its potential as a low-carbon electricity source. Greenhouse gas emissions of nuclear power reported in the life cycle assessment literature vary widely, from a few grams of CO₂ equivalents to more than 100 g/kWh, globally. The reasons for such a variation are often misunderstood when reported and used by policymakers. To fill this gap, one can make LCA models explicit, exploring the role of the most significant parameters, and develop simplified models for the scientific community, policymakers, and the public. We developed a parametric cradle-to-grave life cycle model with 20 potentially significant variables: ore grade, extraction technique, enrichment technique, and power plant construction requirements, among others. Average GHG emissions of global nuclear power in 2020 are found to be 6.1 g CO₂ equiv/kWh, whereas pessimistic and optimistic scenarios provide extreme values of 5.4-122 g CO₂ equiv/kWh. We also provide simplified models, one per environmental impact indicator, which can be used to estimate environmental impacts of electricity generated by a pressurized water reactor without running the full-scale model.