In this study, the fracture behavior of the low-alloy reactor pressure vessel JRQ steel was investigated in the ductile-to-brittle transition region with two different subsized compact tension fracture specimens: 0.18T C(T) and 0.5T C(T). The specimens were extracted from two thin plates (surface and middle) of the large JRQ steel plate, which is well-known to be macroscopically inhomogeneous in terms of brittleness. In particular, the reference temperature T₀ as defined in the ASTM-E1921 standard was calculated for the two plates with the 0.18T C(T) and 0.5T C(T) specimens. A significant difference in the reference temperature T₀ of more than 90 °C as determined with the 0.5T C(T) data was found between the two plates indicating a clear macroscopic inhomogeneity between the two depths. The measured toughness of 0.18T C(T) specimens and corresponding T₀ evaluation showed that the effect of constraint loss was more pronounced for the middle plate due to its lower strength and that the constraint loss effect can be confounded with inhomogeneity. A local approach to fracture model was applied to account for the constraint loss by calibrating a criterion based on critical stressed volume V* and critical stress σ* obtained by finite element simulations. A big difference in the local fracture stress σ* between the two plates was found and based on the deduced local criterion it was shown that the measured 0.18T toughness can be effectively predicted within the temperature range of the ductile-to-brittle transition.