Current implementations of hybrid life cycle assessment (LCA) mostly do not fully exploit valuable information from multi-regional input–output databases by aggregating regional supply chains to the lower geographical resolution of process LCA databases. We propose a method for sampling the various individual regions within the aggregated regional scope of LCA processes. This sampling maximizes the information content of hybrid LCA footprint results by preserving the regional variance, and it allows for regional price distributions from BACI/UN-COMTRADE international trade statistics to be used to simultaneously improve the accuracy of the hybrid model. This work makes the previously hidden regional and price variance explicit and analyzes uncertainty of the hybrid carbon (global warming potential 100, GWP100) and land use footprints arising from these variances, both separately and in combination. We find that the median process footprint intensity increases by 7⁺¹⁸_-3% for the GWP100 due to hybridization, and 90⁺¹⁴³_-23%for the land use footprint. Results show that the magnitude of the footprint uncertainty strongly depends on the product sector of the LCA process and environmental impact considered. In a case study of Swiss household consumption, we find truncation error estimates of 8.4^+9.2_-2.7%  for the GWP100 and 36⁺⁶⁴_-14% for the land use footprint. Our results highlight the importance of regionalization of process LCA databases, as it has the potential to significantly improve both the precision and accuracy of derived hybrid LCA models. This article met the requirements for a gold/gold JIE data openness badge described at http://jie.click/badges.