&lt;sup&gt;165&lt;/sup&gt;Er: a new candidate for Auger electron therapy and its possible cyclotron production from natural holmium targets

Gracheva, Nadezda; Carzaniga, Tommaso Stefano; Schibli, Roger; Braccini, Saverio; van der Meulen, Nicholas P.

doi:10.1016/j.apradiso.2020.109079

¹⁶⁵Er: a new candidate for Auger electron therapy and its possible cyclotron production from natural holmium targets

Gracheva N, Carzaniga TS, Schibli R, Braccini S & van der Meulen NP

Citation

Gracheva, N., Carzaniga, T. S., Schibli, R., Braccini, S., & van der Meulen, N. P. (2020). ¹⁶⁵Er: a new candidate for Auger electron therapy and its possible cyclotron production from natural holmium targets. Applied Radiation and Isotopes, 159, 109079 (8 pp.). https://doi.org/10.1016/j.apradiso.2020.109079

Persistent URL https://www.dora.lib4ri.ch/psi/islandora/object/psi:29739

¹⁶⁵Er, a pure Auger-electron emitter, could be an attractive candidate for targeted radionuclide therapy. Auger electrons possess short penetration paths with high linear energy transfer. In this study, experimental cross-sections of the ¹⁶⁵Ho(p, n)¹⁶⁵Er nuclear reaction were measured and targets irradiated with protons using Injector II cyclotron at Paul Scherrer Institute (Switzerland) and the 18 MeV medical cyclotron laboratory at the University Hospital in Bern. A purification method was developed in order to obtain ¹⁶⁵Er suitable for in vivo applications.

Details

Publication Type

Journal Article

Title

¹⁶⁵Er: a new candidate for Auger electron therapy and its possible cyclotron production from natural holmium targets

Author(s)

Gracheva, Nadezda (2215 Development of Radionuclides)

Carzaniga, Tommaso Stefano

Schibli, Roger (2200 Center for Radiopharmaceutical Sciences)

Braccini, Saverio

van der Meulen, Nicholas P. (4703 Radionuclide Development)

Journal