In addition to the existing strong indications for lepton flavor universality violation in low-energy precision experiments, the CMS Collaboration at CERN recently released an analysis of nonresonant dilepton pairs which could constitute the first sign of lepton flavor universality violation in high-energy searches at the LHC. In this article, we show that the Cabibbo-angle anomaly, an (apparent) violation of first row and column Cabibbo-Kobayashi-Maskawa (CKM) matrix unitarity with ≈3σ significance, and the CMS result can be correlated and commonly explained in a model-independent way by the operator [Q⁽³⁾_ℓq]₁₁₁₁ = (¯ℓ₁γ^μσ^Iℓ₁)(¯q₁γ_μσ^Iq₁). This is possible without violating the bounds from the nonresonant dilepton search of ATLAS (which interestingly also observed slightly more events than expected in the electron channel) nor from R(π) = π → μν/π → eν. We find a combined preference for the new physics hypothesis of 4.5σ and predict 1.0004 < R(π) < 1.0009 (95% C.L.) which can be tested in the near future with the forthcoming results of the PEN experiment.