Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors

Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, Blanc J-B, Gaufreteau D, Liu H, Lin X, Stich A, Kuhn B, Schuler F, Kaiser M, Brun R, Schirmeister T, Kisker C, Diederich F & Haap W
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Giroud, M., Dietzel, U., Anselm, L., Banner, D., Kuglstatter, A., Benz, J., … Haap, W. (2018). Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors. Journal of Medicinal Chemistry, 61(8), 3350-3369. https://doi.org/10.1021/acs.jmedchem.7b01869