Shivashankar, G. V. (2023). Mechanical forces and the 3D genome. Current Opinion in Structural Biology, 83, 102728 (7 pp.). https://doi.org/10.1016/j.sbi.2023.102728
Traditionally, the field of genomics has been studied from a biochemical perspective. Besides chemical influences, cells are subject to a variety of mechanical signals from their surrounding tissue microenvironment. These mechanical signals can not only cause changes to a cell's physical structure but can also lead to alterations in their genomes and gene expression programs. Understanding the mechanical control of genome organization and expression may provide a new perspective on gene regulation.
