The Swiss electricity system is dominated by low-carbon hydro and nuclear generation. The Government's decision to phase-out nuclear energy exacerbates Switzerland's climate change mitigation goals. Response to this challenge requires systemic changes to the energy system, which is generally a long-term, uncertain and systemic process, affected by technology choices across the entire energy system. A comprehensive Swiss TIMES Energy system Model (STEM) with high temporal detail has been developed for the analysis of plausible low-carbon energy pathways focusing on uncertainties related to policy (climate change mitigation and acceptability of new centralised electricity generation) and international fuel prices. Increasing electrification of end-uses is seen across the scenarios, resulting in continuous growth in electricity demands. The electrification of heating and e-mobility substitute direct use of fossil fuels in end-use sectors and contribute to a significant carbon dioxide emission (CO₂) reduction. Centralised gas power plants and renewables become key source of electricity supply. Given the phaseout of nuclear generation, clear policy signals are required to ensure capacity is built to achieve a low-carbon energy system. At the same time, it is also essential to ensure consistency between the electricity sector and end-use energy policies. For the long-term carbon reduction target, some non-cost-effective conservation measures are important early in the period because they are available only at the time of building renovation.