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Biodegradable ultrasmall-in-nano architectures loaded with cisplatin prodrug in combination with ionizing radiation induces DNA damage and apoptosis in pancreatic ductal adenocarcinoma
Che, P. P., Mapanao, A. K., Gregori, A., Ermini, M. L., Zamborlin, A., Capula, M., … Giovannetti, E. (2022). Biodegradable ultrasmall-in-nano architectures loaded with cisplatin prodrug in combination with ionizing radiation induces DNA damage and apoptosis in pancreatic ductal adenocarcinoma. Cancers, 14(12), 3034 (17 pp.). https://doi.org/10.3390/cancers14123034
High precision half-life measurement of the extinct radio-lanthanide Dysprosium-154
Chiera, N. M., Dressler, R., Sprung, P., Talip, Z., & Schumann, D. (2022). High precision half-life measurement of the extinct radio-lanthanide Dysprosium-154. Scientific Reports, 12(1), 8988 (10 pp.). https://doi.org/10.1038/s41598-022-12684-6
Cross section measurement of terbium radioisotopes for an optimized <sup>155</sup>Tb production with an 18 MeV medical PET cyclotron
Dellepiane, G., Casolaro, P., Favaretto, C., Grundler, P. V., Mateu, I., Scampoli, P., … Braccini, S. (2022). Cross section measurement of terbium radioisotopes for an optimized 155Tb production with an 18 MeV medical PET cyclotron. Applied Radiation and Isotopes, 184, 110175 (14 pp.). https://doi.org/10.1016/j.apradiso.2022.110175
Preliminary discovery of small molecule inhibitors of Epidermal Growth Factor Receptor (EGFR) that bind to the extracellular domain
Di Liddo, R., Verona, M., Vaccarin, C., Acquasaliente, L., Schrenk, S., Piccione, M., … Marzaro, G. (2022). Preliminary discovery of small molecule inhibitors of Epidermal Growth Factor Receptor (EGFR) that bind to the extracellular domain. Cancers, 14(15), 3647 (22 pp.). https://doi.org/10.3390/cancers14153647
Half-life measurement of <sup>44</sup>Sc and <sup>44m</sup>Sc
Durán, M. T., Juget, F., Nedjadi, Y., Bailat, C., Grundler, P. V., Talip, Z., … Braccini, S. (2022). Half-life measurement of 44Sc and 44mSc. Applied Radiation and Isotopes, 190, 110507 (10 pp.). https://doi.org/10.1016/j.apradiso.2022.110507
IMPACT conceptual design report
Eichler, R., Kiselev, D., Koschik, A., Knecht, A., van der Meulen, N., Scheibl, R., … Züllig, J. (2022). IMPACT conceptual design report. (PSI Bericht, Report No.: 22-01). Paul Scherrer Institut.
Self-emulsifying formulations to increase the oral bioavailability of 4,6,4′-trimethylangelicin as a possible treatment for cystic fibrosis
Franceschinis, E., Roverso, M., Gabbia, D., De Martin, S., Brusegan, M., Vaccarin, C., … Chilin, A. (2022). Self-emulsifying formulations to increase the oral bioavailability of 4,6,4′-trimethylangelicin as a possible treatment for cystic fibrosis. Pharmaceutics, 14(9), 1806. https://doi.org/10.3390/pharmaceutics14091806
EANM guideline on quality risk management for radiopharmaceuticals
Gillings, N., Hjelstuen, O., Behe, M., Decristoforo, C., Elsinga, P. H., Ferrari, V., … Walte, A. (2022). EANM guideline on quality risk management for radiopharmaceuticals. European Journal of Nuclear Medicine and Molecular Imaging, 49, 3353-3364. https://doi.org/10.1007/s00259-022-05738-4
Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)
Grzmil, M., Boersema, P., Sharma, A., Blanc, A., Imobersteg, S., Pruschy, M., … Behe, M. (2022). Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT). Journal of Hematology & Oncology, 15(1), 123 (5 pp.). https://doi.org/10.1186/s13045-022-01343-y
Active bone marrow S-values for the low-energy electron emitter terbium-161 compared to S-values for lutetium-177 and yttrium-90
Hemmingsson, J., Svensson, J., van der Meulen, N. P., Müller, C., & Bernhardt, P. (2022). Active bone marrow S-values for the low-energy electron emitter terbium-161 compared to S-values for lutetium-177 and yttrium-90. EJNMMI Physics, 9(1), 65 (13 pp.). https://doi.org/10.1186/s40658-022-00495-7
Precise activity measurements of medical radionuclides using an ionization chamber: a case study with Terbium-161
Juget, F., Talip, Z., Nedjadi, Y., Durán, M. T., Grundler, P. V., Zeevaart, J. R., … Bailat, C. (2022). Precise activity measurements of medical radionuclides using an ionization chamber: a case study with Terbium-161. EJNMMI Physics, 9(1), 19 (18 pp.). https://doi.org/10.1186/s40658-022-00448-0
Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects
Miller, I. S., Khan, S., Shiels, L. P., Das, S., O' Farrell, A. C., Connor, K., … Byrne, A. T. (2022). Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects. Cancer Medicine, 11(20), 3820-3836. https://doi.org/10.1002/cam4.4756
A multispecific anti-CD40 DARPin construct induces tumor-selective CD40 activation and tumor regression
Rigamonti, N., Veitonmäki, N., Domke, C., Barsin, S., Jetzer, S., Abdelmotaleb, O., … Trail, P. A. (2022). A multispecific anti-CD40 DARPin construct induces tumor-selective CD40 activation and tumor regression. Cancer Immunology Research, 10(5), 626-640. https://doi.org/10.1158/2326-6066.CIR-21-0553
Translational immunoPET imaging using a radiolabeled GD2-specific antibody in neuroblastoma
Schmitt, J., Schwenck, J., Maurer, A., Przybille, M., Sonanini, D., Reischl, G., … Pichler, B. J. (2022). Translational immunoPET imaging using a radiolabeled GD2-specific antibody in neuroblastoma. Theranostics, 12(13), 5615-5630. https://doi.org/10.7150/thno.56736
Antibody-guided molecular imaging of <em>Aspergillus </em>lung infections in leukemia patients
Schwenck, J., Maurer, A., Beziere, N., Fiz, F., Boschetti, F., Geistlich, S., … Thornton, C. (2022). Antibody-guided molecular imaging of Aspergillus lung infections in leukemia patients. Journal of Nuclear Medicine, 63(9), 1450-1451. https://doi.org/10.2967/jnumed.121.263251
Chelation of theranostic copper radioisotopes with S-rich macrocycles: from radiolabelling of copper-64 to in vivo investigation
Tosato, M., Verona, M., Favaretto, C., Pometti, M., Zanoni, G., Scopelliti, F., … Asti, M. (2022). Chelation of theranostic copper radioisotopes with S-rich macrocycles: from radiolabelling of copper-64 to in vivo investigation. Molecules, 27(13), 4158 (19 pp.). https://doi.org/10.3390/molecules27134158
Targeting virulence regulation to disarm <em>Acinetobacter baumannii</em> pathogenesis
Trebosc, V., Lucchini, V., Narwal, M., Wicki, B., Gartenmann, S., Schellhorn, B., … Pieren, M. (2022). Targeting virulence regulation to disarm Acinetobacter baumannii pathogenesis. Virulence, 13(1), 1868-1883. https://doi.org/10.1080/21505594.2022.2135273
Impact of the mouse model and molar amount of injected ligand on the tissue distribution profile of PSMA radioligands
Tschan, V. J., Borgna, F., Schibli, R., & Müller, C. (2022). Impact of the mouse model and molar amount of injected ligand on the tissue distribution profile of PSMA radioligands. European Journal of Nuclear Medicine and Molecular Imaging, 49, 470-480. https://doi.org/10.1007/s00259-021-05446-5
Preclinical investigations using [<sup>177</sup>Lu]Lu-Ibu-DAB-PSMA toward its clinical translation for radioligand therapy of prostate cancer
Tschan, V. J., Borgna, F., Busslinger, S. D., Stirn, M., Monné Rodriguez, J. M., Bernhardt, P., … Müller, C. (2022). Preclinical investigations using [177Lu]Lu-Ibu-DAB-PSMA toward its clinical translation for radioligand therapy of prostate cancer. European Journal of Nuclear Medicine and Molecular Imaging, 49, 3639-3650. https://doi.org/10.1007/s00259-022-05837-2
New TMA (4,6,4′-trimethyl angelicin) analogues as anti-inflammatory agents in the treatment of cystic fibrosis lung disease
Tupini, C., Chilin, A., Rossi, A., De Fino, I., Bragonzi, A., D’Aversa, E., … Lampronti, I. (2022). New TMA (4,6,4′-trimethyl angelicin) analogues as anti-inflammatory agents in the treatment of cystic fibrosis lung disease. International Journal of Molecular Sciences, 23(22), 14483 (20 pp.). https://doi.org/10.3390/ijms232214483