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Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains
Abrami, L., Audagnotto, M., Ho, S., Marcaida, M. J., Mesquita, F. S., Anwar, M. U., … van der Goot, F. G. (2021). Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains. Nature Chemical Biology, 17(4), 438-447. https://doi.org/10.1038/s41589-021-00753-2
Mechanisms of regulation and diverse activities of tau-tubulin kinase (TTBK) isoforms
Bao, C., Bajrami, B., Marcotte, D. J., Chodaparambil, J. V., Kerns, H. M., Henderson, J., … Dillon, G. M. (2021). Mechanisms of regulation and diverse activities of tau-tubulin kinase (TTBK) isoforms. Cellular and Molecular Neurobiology, 41, 669-685. https://doi.org/10.1007/s10571-020-00875-6
Structure-based design of high-affinity macrocyclic FKBP51 inhibitors
Bauder, M., Meyners, C., Purder, P. L., Merz, S., Sugiarto, W. O., Voll, A. M., … Hausch, F. (2021). Structure-based design of high-affinity macrocyclic FKBP51 inhibitors. Journal of Medicinal Chemistry, 64(6), 3320-3349. https://doi.org/10.1021/acs.jmedchem.0c02195
<em>In vitro</em> reconstitution of a five-step pathway for bacterial ergothioneine catabolism
Beliaeva, M. A., Leisinger, F., & Seebeck, F. P. (2021). In vitro reconstitution of a five-step pathway for bacterial ergothioneine catabolism. ACS Chemical Biology, 16(2), 397-403. https://doi.org/10.1021/acschembio.0c00968
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
Berger, B. T., Amaral, M., Kokh, D. B., Nunes-Alves, A., Musil, D., Heinrich, T., … Knapp, S. (2021). Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell Chemical Biology. https://doi.org/10.1016/j.chembiol.2021.01.003
Evaluation of scanning transmission X-ray microscopy at the Mn L<sub>2,3</sub>-edges as a potential probe for manganese redox state in natural silicates
Bourdelle, F., Lloret, E., Durand, C., & Airaghi, L. (2021). Evaluation of scanning transmission X-ray microscopy at the Mn L2,3-edges as a potential probe for manganese redox state in natural silicates. Physics and Chemistry of Minerals, 48, 18 (12 pp.). https://doi.org/10.1007/s00269-021-01142-w
Structure of high-risk papillomavirus 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation
Conrady, M. C., Suarez, I., Gogl, G., Frecot, D. I., Bonhoure, A., Kostmann, C., … Simon, C. (2021). Structure of high-risk papillomavirus 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation. Journal of Virology, 95(2), e00730-20 (15 pp.). https://doi.org/10.1128/JVI.00730-20
Structure–function dataset reveals environment effects within a fluorescent protein model system
De Zitter, E., Hugelier, S., Duwé, S., Vandenberg, W., Tebo, A. G., Van Meervelt, L., & Dedecker, P. (2021). Structure–function dataset reveals environment effects within a fluorescent protein model system. Angewandte Chemie International Edition, 60(18), 10073-10081. https://doi.org/10.1002/anie.202015201
Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology
Dimovasili, C., Fadouloglou, V. E., Kefala, A., Providaki, M., Kotsifaki, D., Kanavouras, K., … Kokkinidis, M. (2021). Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology. Journal of Neurochemistry. https://doi.org/10.1111/jnc.15296
A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition
Focht, D., Neumann, C., Lyons, J., Eguskiza Bilbao, A., Blunck, R., Malinauskaite, L., … Nissen, P. (2021). A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition. EMBO Journal, 40(1), e105164 (13 pp.). https://doi.org/10.15252/embj.2020105164
Catanthus, an extinct magnoliid flower from the early cretaceous of portugal
Friis, E. M., Crane, P. R., & Pedersen, K. R. (2021). Catanthus, an extinct magnoliid flower from the early cretaceous of portugal. International Journal of Plant Sciences, 182(1), 28-45. https://doi.org/10.1086/711081
Structure-based approaches to improving selectivity through utilizing explicit water molecules: discovery of selective <em>β</em>-secretase (BACE1) inhibitors over BACE2
Fujimoto, K., Yoshida, S., Tadano, G., Asada, N., Fuchino, K., Suzuki, S., … Kusakabe, Kichi. (2021). Structure-based approaches to improving selectivity through utilizing explicit water molecules: discovery of selective β-secretase (BACE1) inhibitors over BACE2. Journal of Medicinal Chemistry, 64(6), 3075-3085. https://doi.org/10.1021/acs.jmedchem.0c01858
Trends in the series of ammine rare-earth-metal borohydrides: relating structural and thermal properties
Grinderslev, J. B., & Jensen, T. R. (2021). Trends in the series of ammine rare-earth-metal borohydrides: relating structural and thermal properties. Inorganic Chemistry, 60(4), 2573-2589. https://doi.org/10.1021/acs.inorgchem.0c03464
A biosensor for the direct visualization of auxin
Herud-Sikimić, O., Stiel, A. C., Kolb, M., Shanmugaratnam, S., Berendzen, K. W., Feldhaus, C., … Jürgens, G. (2021). A biosensor for the direct visualization of auxin. Nature, 592, 768-772. https://doi.org/10.1038/s41586-021-03425-2
The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs
Hillen, H. S., Markov, D. A., Wojtas, I. D., Hofmann, K. B., Lidschreiber, M., Cowan, A. T., … Anikin, M. (2021). The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs. Proceedings of the National Academy of Sciences of the United States of America PNAS, 118(15), e2009329118 (8 pp.). https://doi.org/10.1073/pnas.2009329118
BI-3406, a potent and selective SOS1–KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition
Hofmann, M. H., Gmachl, M., Ramharter, J., Savarese, F., Gerlach, D., Marszalek, J. R., … Kraut, N. (2021). BI-3406, a potent and selective SOS1–KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition. Cancer Discovery, 11(1), 142-157. https://doi.org/10.1158/2159-8290.CD-20-0142
Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma
Jiang, B., Jiang, J., Kaltheuner, I. H., Iniguez, A. B., Anand, K., Ferguson, F. M., … Gray, N. S. (2021). Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. European Journal of Medicinal Chemistry, 221, 113481 (16 pp.). https://doi.org/10.1016/j.ejmech.2021.113481
Insulin binding to the analytical antibody sandwich pair OXI‐005 and HUI‐018: epitope mapping and binding properties
Johansson, E., Wu, X., Yu, B., Yang, Z., Cao, Z., Wiberg, C., … Poulsen, F. (2021). Insulin binding to the analytical antibody sandwich pair OXI‐005 and HUI‐018: epitope mapping and binding properties. Protein Science, 30(2), 485-496. https://doi.org/10.1002/pro.4009
Nucleation and growth of gas bubbles in AlSi8Mg4 foam investigated by X-ray tomoscopy
Kamm, P. H., Neu, T. R., García-Moreno, F., & Banhart, J. (2021). Nucleation and growth of gas bubbles in AlSi8Mg4 foam investigated by X-ray tomoscopy. Acta Materialia, 206, 116583 (16 pp.). https://doi.org/10.1016/j.actamat.2020.116583
The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase
Kaur, H., Jakob, R. P., Marzinek, J. K., Green, R., Imai, Y., Bolla, J. R., … Hiller, S. (2021). The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase. Nature, 593, 125-129. https://doi.org/10.1038/s41586-021-03455-w