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Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains
Abrami, L., Audagnotto, M., Ho, S., Marcaida, M. J., Mesquita, F. S., Anwar, M. U., … van der Goot, F. G. (2021). Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains. Nature Chemical Biology, 17(4), 438-447. https://doi.org/10.1038/s41589-021-00753-2
Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases
Akaki, T., Bessho, Y., Ito, T., Fujioka, S., Ubukata, M., Mori, G., … Adachi, T. (2021). Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorganic and Medicinal Chemistry, 44, 116283 (15 pp.). https://doi.org/10.1016/j.bmc.2021.116283
Time-resolved study of thermal decomposition process of (NH<sub>4</sub>)<sub>2</sub>[PtCl<sub>6</sub>]: intermediates and Pt nucleation
Asanova, T. I., Fedorova, E. A., Asanov, I. P., Yusenko, K. V., Gerasimov, E. Y., La Fontaine, C., … Korenev, S. V. (2021). Time-resolved study of thermal decomposition process of (NH4)2[PtCl6]: intermediates and Pt nucleation. Vacuum, 194, 110590 (12 pp.). https://doi.org/10.1016/j.vacuum.2021.110590
Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody
Augsberger, C., Hänel, G., Xu, W., Pulko, V., Hanisch, L. J., Augustin, A., … Subklewe, M. (2021). Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody. Blood, 138(25), 2655 (15 pp.)-2669. https://doi.org/10.1182/blood.2020010477
Mechanisms of regulation and diverse activities of tau-tubulin kinase (TTBK) isoforms
Bao, C., Bajrami, B., Marcotte, D. J., Chodaparambil, J. V., Kerns, H. M., Henderson, J., … Dillon, G. M. (2021). Mechanisms of regulation and diverse activities of tau-tubulin kinase (TTBK) isoforms. Cellular and Molecular Neurobiology, 41, 669-685. https://doi.org/10.1007/s10571-020-00875-6
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold
Basler, S., Studer, S., Zou, Y., Mori, T., Ota, Y., Camus, A., … Hilvert, D. (2021). Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold. Nature Chemistry, 13(3), 231-235. https://doi.org/10.1038/s41557-020-00628-4
Structure-based design of high-affinity macrocyclic FKBP51 inhibitors
Bauder, M., Meyners, C., Purder, P. L., Merz, S., Sugiarto, W. O., Voll, A. M., … Hausch, F. (2021). Structure-based design of high-affinity macrocyclic FKBP51 inhibitors. Journal of Medicinal Chemistry, 64(6), 3320-3349. https://doi.org/10.1021/acs.jmedchem.0c02195
&lt;em&gt;In vitro&lt;/em&gt; reconstitution of a five-step pathway for bacterial ergothioneine catabolism
Beliaeva, M. A., Leisinger, F., & Seebeck, F. P. (2021). In vitro reconstitution of a five-step pathway for bacterial ergothioneine catabolism. ACS Chemical Biology, 16(2), 397-403. https://doi.org/10.1021/acschembio.0c00968
Novel β-Glucocerebrosidase activators that bind to a new pocket at a dimer interface and induce dimerization
Benz, J., Rufer, A. C., Huber, S., Ehler, A., Hug, M., Topp, A., … Rodríguez Sarmiento, R. M. (2021). Novel β-Glucocerebrosidase activators that bind to a new pocket at a dimer interface and induce dimerization. Angewandte Chemie International Edition, 60(10), 5436-5442. https://doi.org/10.1002/anie.202013890
Reduction mechanisms of anticancer osmium(VI) complexes revealed by atomic telemetry and theoretical calculations
Berger, G., Wach, A., Sá, J., & Szlachetko, J. (2021). Reduction mechanisms of anticancer osmium(VI) complexes revealed by atomic telemetry and theoretical calculations. Inorganic Chemistry, 60(9), 6663-6671. https://doi.org/10.1021/acs.inorgchem.1c00467
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
Berger, B. T., Amaral, M., Kokh, D. B., Nunes-Alves, A., Musil, D., Heinrich, T., … Knapp, S. (2021). Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell Chemical Biology, 28(5), 686-698. https://doi.org/10.1016/j.chembiol.2021.01.003
Structure-based optimization of a fragment-like TLR8 binding screening hit to an <em>in vivo</em> efficacious TLR7/8 antagonist
Betschart, C., Faller, M., Zink, F., Hemmig, R., Blank, J., Vangrevelinghe, E., … Knoepfel, T. (2021). Structure-based optimization of a fragment-like TLR8 binding screening hit to an in vivo efficacious TLR7/8 antagonist. ACS Medicinal Chemistry Letters, 13(4), 658-664. https://doi.org/10.1021/acsmedchemlett.1c00696
Evaluation of scanning transmission X-ray microscopy at the Mn L<sub>2,3</sub>-edges as a potential probe for manganese redox state in natural silicates
Bourdelle, F., Lloret, E., Durand, C., & Airaghi, L. (2021). Evaluation of scanning transmission X-ray microscopy at the Mn L2,3-edges as a potential probe for manganese redox state in natural silicates. Physics and Chemistry of Minerals, 48, 18 (12 pp.). https://doi.org/10.1007/s00269-021-01142-w
Architecture of the membrane-bound cytochrome c heme lyase CcmF
Brausemann, A., Zhang, L., Ilcu, L., & Einsle, O. (2021). Architecture of the membrane-bound cytochrome c heme lyase CcmF. Nature Chemical Biology, 17(7), 800-805. https://doi.org/10.1038/s41589-021-00793-8
From structure to clinic: design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease
Brown, A. J. H., Bradley, S. J., Marshall, F. H., Brown, G. A., Bennett, K. A., Brown, J., … Tobin, A. B. (2021). From structure to clinic: design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. Cell, 184(24), 5886-5901.e22. https://doi.org/10.1016/j.cell.2021.11.001
Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors
Brullo, C., Rapetti, F., Abbate, S., Prosdocimi, T., Torretta, A., Semrau, M., … Bruno, O. (2021). Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors. European Journal of Medicinal Chemistry, 223, 113638 (13 pp.). https://doi.org/10.1016/j.ejmech.2021.113638
Optimization of a screening hit toward M2912, an oral tankyrase inhibitor with antitumor activity in colorectal cancer models
Buchstaller, H. P., Anlauf, U., Dorsch, D., Kögler, S., Kuhn, D., Lehmann, M., … Esdar, C. (2021). Optimization of a screening hit toward M2912, an oral tankyrase inhibitor with antitumor activity in colorectal cancer models. Journal of Medicinal Chemistry, 64(14), 10371-10392. https://doi.org/10.1021/acs.jmedchem.1c00800
The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1
Böhm, R., Imseng, S., Jakob, R. P., Hall, M. N., Maier, T., & Hiller, S. (2021). The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1. Molecular Cell, 81(11), 2403-2416. https://doi.org/10.1016/j.molcel.2021.03.031
Design and evolution of chimeric streptavidin for protein-enabled dual gold catalysis
Christoffel, F., Igareta, N. V., Pellizzoni, M. M., Tiessler-Sala, L., Lozhkin, B., Spiess, D. C., … Ward, T. R. (2021). Design and evolution of chimeric streptavidin for protein-enabled dual gold catalysis. Nature Catalysis, 4(8), 643-653. https://doi.org/10.1038/s41929-021-00651-9
Structure of high-risk papillomavirus 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation
Conrady, M. C., Suarez, I., Gogl, G., Frecot, D. I., Bonhoure, A., Kostmann, C., … Simon, C. (2021). Structure of high-risk papillomavirus 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation. Journal of Virology, 95(2), e00730-20 (15 pp.). https://doi.org/10.1128/JVI.00730-20
 

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