| Bistable photoswitch allows in vivo control of hematopoiesis
Albert, L., Nagpal, J., Steinchen, W., Zhang, L., Werel, L., Djokovic, N., … Vázquez, O. (2022). Bistable photoswitch allows in vivo control of hematopoiesis. ACS Central Science, 8(1), 57-66. https://doi.org/10.1021/acscentsci.1c00434 |
| Unraveling the mechanism of electrically induced adhesive debonding: a spectro-microscopic study
Anduix-Canto, C., Peral, D., Pérez-Padilla, V., Diaz-Rovira, A. M., Belmez Lledó, A., Orme, C. A., … Chou, K. W. (2022). Unraveling the mechanism of electrically induced adhesive debonding: a spectro-microscopic study. Advanced Materials Interfaces, 9(1), 2101447 (10 pp.). https://doi.org/10.1002/admi.202101447 |
| Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction
Begnini, F., Geschwindner, S., Johansson, P., Wissler, L., Lewis, R. J., Danelius, E., … Kihlberg, J. (2022). Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction. Journal of Medicinal Chemistry, 65(4), 3473-3517. https://doi.org/10.1021/acs.jmedchem.1c01975 |
| NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems
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| Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B<sub>12</sub> uptake route
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| Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
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| Structural organization of the spongy mesophyll
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| Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification
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| Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases
Chrustowicz, J., Sherpa, D., Teyra, J., Loke, M. S., Popowicz, G. M., Basquin, J., … Schulman, B. A. (2022). Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases. Journal of Molecular Biology, 434(2), 167347 (22 pp.). https://doi.org/10.1016/j.jmb.2021.167347 |
| Structure-based design of a novel class of autotaxin inhibitors based on endogenous allosteric modulators
Clark, J. M., Salgado-Polo, F., Macdonald, S. J. F., Barrett, T. N., Perrakis, A., & Jamieson, C. (2022). Structure-based design of a novel class of autotaxin inhibitors based on endogenous allosteric modulators. Journal of Medicinal Chemistry, 65(8), 6338-6351. https://doi.org/10.1021/acs.jmedchem.2c00368 |
| Dichlorophenylpyridine-based molecules inhibit furin through an induced-fit mechanism
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| An atomistic model describing the structure and morphology of Cu-doped C-S-H hardening accelerator nanoparticles
Dal Sasso, G., Dalconi, M. C., Ferrari, G., Pedersen, J. S., Tamburini, S., Bertolotti, F., … Artioli, G. (2022). An atomistic model describing the structure and morphology of Cu-doped C-S-H hardening accelerator nanoparticles. Nanomaterials, 12(3), 342 (21 pp.). https://doi.org/10.3390/nano12030342 |
| Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly
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| Crystal structure of the α<sub>1B</sub>-adrenergic receptor reveals molecular determinants of selective ligand recognition
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| Identification of pyrimidine-based lead compounds for understudied kinases implicated in driving neurodegeneration
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| Engineered HaloTag variants for fluorescence lifetime multiplexing
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| Crystal structure of plasmoredoxin, a redox-active protein unique for malaria parasites
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| Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE
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| High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system
Heim, C., & Hartmann, M. D. (2022). High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system. Acta Crystallographica Section D: Structural Biology, 78, 290-298. https://doi.org/10.1107/S2059798322000092 |
| A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family
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