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Bistable photoswitch allows in vivo control of hematopoiesis
Albert, L., Nagpal, J., Steinchen, W., Zhang, L., Werel, L., Djokovic, N., … Vázquez, O. (2022). Bistable photoswitch allows in vivo control of hematopoiesis. ACS Central Science, 8(1), 57-66. https://doi.org/10.1021/acscentsci.1c00434
Unraveling the mechanism of electrically induced adhesive debonding: a spectro-microscopic study
Anduix-Canto, C., Peral, D., Pérez-Padilla, V., Diaz-Rovira, A. M., Belmez Lledó, A., Orme, C. A., … Chou, K. W. (2022). Unraveling the mechanism of electrically induced adhesive debonding: a spectro-microscopic study. Advanced Materials Interfaces, 9(1), 2101447 (10 pp.). https://doi.org/10.1002/admi.202101447
Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction
Begnini, F., Geschwindner, S., Johansson, P., Wissler, L., Lewis, R. J., Danelius, E., … Kihlberg, J. (2022). Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction. Journal of Medicinal Chemistry, 65(4), 3473-3517. https://doi.org/10.1021/acs.jmedchem.1c01975
NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems
Biebl, M. M., Delhommel, F., Faust, O., Zak, K. M., Agam, G., Guo, X., … Buchner, J. (2022). NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems. Molecular Cell, 82(3), 555-569.e7. https://doi.org/10.1016/j.molcel.2021.12.031
Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B<sub>12</sub> uptake route
Bloch, J. S., Sequeira, J. M., Ramírez, A. S., Quadros, E. V., & Locher, K. P. (2022). Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B12 uptake route. FASEB Journal, 36(4), e22222 (11 pp.). https://doi.org/10.1096/fj.202101376RR
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Bonagas, N., Gustafsson, N. M. S., Henriksson, M., Marttila, P., Gustafsson, R., Wiita, E., … Helleday, T. (2022). Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nature Cancer, 3(2), 156-172. https://doi.org/10.1038/s43018-022-00331-y
Structural organization of the spongy mesophyll
Borsuk, A. M., Roddy, A. B., Théroux‐Rancourt, G., & Brodersen, C. R. (2022). Structural organization of the spongy mesophyll. New Phytologist, 234(3), 946-960. https://doi.org/10.1111/nph.17971
Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification
Bärland, N., Rueff, A. S., Cebrero, G., Hutter, C. A. J., Seeger, M. A., Veening, J. W., & Perez, C. (2022). Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification. Science Advances, 8(9), eabm1122 (14 pp.). https://doi.org/10.1126/sciadv.abm1122
Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases
Chrustowicz, J., Sherpa, D., Teyra, J., Loke, M. S., Popowicz, G. M., Basquin, J., … Schulman, B. A. (2022). Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases. Journal of Molecular Biology, 434(2), 167347 (22 pp.). https://doi.org/10.1016/j.jmb.2021.167347
Structure-based design of a novel class of autotaxin inhibitors based on endogenous allosteric modulators
Clark, J. M., Salgado-Polo, F., Macdonald, S. J. F., Barrett, T. N., Perrakis, A., & Jamieson, C. (2022). Structure-based design of a novel class of autotaxin inhibitors based on endogenous allosteric modulators. Journal of Medicinal Chemistry, 65(8), 6338-6351. https://doi.org/10.1021/acs.jmedchem.2c00368
Dichlorophenylpyridine-based molecules inhibit furin through an induced-fit mechanism
Dahms, S. O., Schnapp, G., Winter, M., Büttner, F. H., Schlepütz, M., Gnamm, C., … Brandstetter, H. (2022). Dichlorophenylpyridine-based molecules inhibit furin through an induced-fit mechanism. ACS Chemical Biology, 17(4), 816-821. https://doi.org/10.1021/acschembio.2c00103
An atomistic model describing the structure and morphology of Cu-doped C-S-H hardening accelerator nanoparticles
Dal Sasso, G., Dalconi, M. C., Ferrari, G., Pedersen, J. S., Tamburini, S., Bertolotti, F., … Artioli, G. (2022). An atomistic model describing the structure and morphology of Cu-doped C-S-H hardening accelerator nanoparticles. Nanomaterials, 12(3), 342 (21 pp.). https://doi.org/10.3390/nano12030342
Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly
De Vries, T., Martelly, W., Campagne, S., Sabath, K., Sarnowski, C. P., Wong, J., … Allain, F. H. T. (2022). Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly. Proceedings of the National Academy of Sciences of the United States of America PNAS, 119(6), e2114092119 (11 pp.). https://doi.org/10.1073/pnas.2114092119
Crystal structure of the α<sub>1B</sub>-adrenergic receptor reveals molecular determinants of selective ligand recognition
Deluigi, M., Morstein, L., Schuster, M., Klenk, C., Merklinger, L., Cridge, R. R., … Plückthun, A. (2022). Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition. Nature Communications, 13(1), 382. https://doi.org/10.1038/s41467-021-27911-3
Identification of pyrimidine-based lead compounds for understudied kinases implicated in driving neurodegeneration
Drewry, D. H., Annor-Gyamfi, J. K., Wells, C. I., Pickett, J. E., Dederer, V., Preuss, F., … Axtman, A. D. (2022). Identification of pyrimidine-based lead compounds for understudied kinases implicated in driving neurodegeneration. Journal of Medicinal Chemistry, 65(2), 1313-1328. https://doi.org/10.1021/acs.jmedchem.1c00440
Engineered HaloTag variants for fluorescence lifetime multiplexing
Frei, M. S., Tarnawski, M., Roberti, M. J., Koch, B., Hiblot, J., & Johnsson, K. (2022). Engineered HaloTag variants for fluorescence lifetime multiplexing. Nature Methods, 19(1), 65-70. https://doi.org/10.1038/s41592-021-01341-x
Crystal structure of plasmoredoxin, a redox-active protein unique for malaria parasites
Fritz-Wolf, K., Bathke, J., Rahlfs, S., & Becker, K. (2022). Crystal structure of plasmoredoxin, a redox-active protein unique for malaria parasites. Current Research in Structural Biology, 4, 87-95. https://doi.org/10.1016/j.crstbi.2022.03.004
Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE
García-Alija, M., Du, J. J., Ordóñez, I., Diz-Vallenilla, A., Moraleda-Montoya, A., Sultana, N., … Guerin, M. E. (2022). Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE. Nature Communications, 13(1), 1137 (17 pp.). https://doi.org/10.1038/s41467-022-28722-w
High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system
Heim, C., & Hartmann, M. D. (2022). High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system. Acta Crystallographica Section D: Structural Biology, 78, 290-298. https://doi.org/10.1107/S2059798322000092
A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family
Hermanns, T., Pichlo, C., Baumann, U., & Hofmann, K. (2022). A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family. Nature Communications, 13(1), 401 (14 pp.). https://doi.org/10.1038/s41467-022-28049-6