| Bistable photoswitch allows in vivo control of hematopoiesis
Albert, L., Nagpal, J., Steinchen, W., Zhang, L., Werel, L., Djokovic, N., … Vázquez, O. (2022). Bistable photoswitch allows in vivo control of hematopoiesis. ACS Central Science, 8(1), 57-66. https://doi.org/10.1021/acscentsci.1c00434 |
| Structural insights into the mechanism of archaellar rotational switching
Altegoer, F., Quax, T. E. F., Weiland, P., Nußbaum, P., Giammarinaro, P. I., Patro, M., … Bange, G. (2022). Structural insights into the mechanism of archaellar rotational switching. Nature Communications, 13(1), 2857 (12 pp.). https://doi.org/10.1038/s41467-022-30358-9 |
| Unraveling the mechanism of electrically induced adhesive debonding: a spectro-microscopic study
Anduix-Canto, C., Peral, D., Pérez-Padilla, V., Diaz-Rovira, A. M., Belmez Lledó, A., Orme, C. A., … Chou, K. W. (2022). Unraveling the mechanism of electrically induced adhesive debonding: a spectro-microscopic study. Advanced Materials Interfaces, 9(1), 2101447 (10 pp.). https://doi.org/10.1002/admi.202101447 |
| Structural insights into light-driven anion pumping in cyanobacteria
Astashkin, R., Kovalev, K., Bukhdruker, S., Vaganova, S., Kuzmin, A., Alekseev, A., … Gordeliy, V. (2022). Structural insights into light-driven anion pumping in cyanobacteria. Nature Communications, 13(1), 6460 (13 pp.). https://doi.org/10.1038/s41467-022-34019-9 |
| Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
Astro, V., Ramirez-Calderon, G., Pennucci, R., Caroli, J., Saera-Vila, A., Cardona-Londoño, K., … Adamo, A. (2022). Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism. iScience, 25(7), 104665 (32 pp.). https://doi.org/10.1016/j.isci.2022.104665 |
| Fast labeled spanning tree in binary irregular graph pyramids
Banaeyan, M., & Kropatsch, W. G. (2022). Fast labeled spanning tree in binary irregular graph pyramids. Journal of Engineering Research and Sciences, 1(10), 69-78. https://doi.org/10.55708/js0110009 |
| Biochemical and structural characterization of thermostable GH159 glycoside hydrolases exhibiting α-L-arabinofuranosidase activity
Baudrexl, M., Fida, T., Berk, B., Schwarz, W. H., Zverlov, V. V., Groll, M., & Liebl, W. (2022). Biochemical and structural characterization of thermostable GH159 glycoside hydrolases exhibiting α-L-arabinofuranosidase activity. Frontiers in Molecular Biosciences, 9, 907439 (15 pp.). https://doi.org/10.3389/fmolb.2022.907439 |
| Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction
Begnini, F., Geschwindner, S., Johansson, P., Wissler, L., Lewis, R. J., Danelius, E., … Kihlberg, J. (2022). Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction. Journal of Medicinal Chemistry, 65(4), 3473-3517. https://doi.org/10.1021/acs.jmedchem.1c01975 |
| Slow magnetic relaxation of dy adatoms with in-plane magnetic anisotropy on a two-dimensional electron gas
Bellini, V., Rusponi, S., Kolorenč, J., Mahatha, S. K., Valbuena, M. A., Persichetti, L., … Barla, A. (2022). Slow magnetic relaxation of dy adatoms with in-plane magnetic anisotropy on a two-dimensional electron gas. ACS Nano, 16(7), 11182-11193. https://doi.org/10.1021/acsnano.2c04048 |
| 1-deazaguanosine-modified RNA: the missing piece for functional RNA atomic mutagenesis
Bereiter, R., Renard, E., Breuker, K., Kreutz, C., Ennifar, E., & Micura, R. (2022). 1-deazaguanosine-modified RNA: the missing piece for functional RNA atomic mutagenesis. Journal of the American Chemical Society, 144(23), 10344-10352. https://doi.org/10.1021/jacs.2c01877 |
| Crystal structure of <em>Leishmania donovani</em> glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain
Berneburg, I., Rahlfs, S., Becker, K., & Fritz-Wolf, K. (2022). Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain. Communications Biology, 5(1), 1353 (14 pp.). https://doi.org/10.1038/s42003-022-04307-7 |
| Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors
Beroza, P., Crawford, J. J., Ganichkin, O., Gendelev, L., Harris, S. F., Klein, R., … Lemmen, C. (2022). Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors. Nature Communications, 13(1), 6447 (10 pp.). https://doi.org/10.1038/s41467-022-33981-8 |
| NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems
Biebl, M. M., Delhommel, F., Faust, O., Zak, K. M., Agam, G., Guo, X., … Buchner, J. (2022). NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems. Molecular Cell, 82(3), 555-569.e7. https://doi.org/10.1016/j.molcel.2021.12.031 |
| Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B<sub>12</sub> uptake route
Bloch, J. S., Sequeira, J. M., Ramírez, A. S., Quadros, E. V., & Locher, K. P. (2022). Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B12 uptake route. FASEB Journal, 36(4), e22222 (11 pp.). https://doi.org/10.1096/fj.202101376RR |
| Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Bonagas, N., Gustafsson, N. M. S., Henriksson, M., Marttila, P., Gustafsson, R., Wiita, E., … Helleday, T. (2022). Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nature Cancer, 3(2), 156-172. https://doi.org/10.1038/s43018-022-00331-y |
| Structural organization of the spongy mesophyll
Borsuk, A. M., Roddy, A. B., Théroux‐Rancourt, G., & Brodersen, C. R. (2022). Structural organization of the spongy mesophyll. New Phytologist, 234(3), 946-960. https://doi.org/10.1111/nph.17971 |
| Application of phase-field fracture theories and digital volume correlation to synchrotron X-ray monitored fractures in human trabecular bone: a case study
Braesch-Andersen, A., Wu, D., Ferguson, S. J., Persson, C., & Isaksson, P. (2022). Application of phase-field fracture theories and digital volume correlation to synchrotron X-ray monitored fractures in human trabecular bone: a case study. Journal of the Mechanical Behavior of Biomedical Materials, 135, 105446 (16 pp.). https://doi.org/10.1016/j.jmbbm.2022.105446 |
| Fragment optimization of reversible binding to the switch II pocket on KRAS leads to a potent, in vivo active KRAS<sup>G12C</sup> inhibitor
Bröker, J., Waterson, A. G., Smethurst, C., Kessler, D., Böttcher, J., Mayer, M., … Fesik, S. W. (2022). Fragment optimization of reversible binding to the switch II pocket on KRAS leads to a potent, in vivo active KRASG12C inhibitor. Journal of Medicinal Chemistry, 65(21), 14614-14629. https://doi.org/10.1021/acs.jmedchem.2c01120 |
| Discovery of RMC-5552, a selective bi-steric inhibitor of mTORC1, for the treatment of mTORC1-activated tumors
Burnett, G. L., Yang, Y. C., Aggen, J. B., Pitzen, J., Gliedt, M. K., Semko, C. M., … Gill, A. L. (2022). Discovery of RMC-5552, a selective bi-steric inhibitor of mTORC1, for the treatment of mTORC1-activated tumors. Journal of Medicinal Chemistry, 66(1), 149-169. https://doi.org/10.1021/acs.jmedchem.2c01658 |
| Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification
Bärland, N., Rueff, A. S., Cebrero, G., Hutter, C. A. J., Seeger, M. A., Veening, J. W., & Perez, C. (2022). Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification. Science Advances, 8(9), eabm1122 (14 pp.). https://doi.org/10.1126/sciadv.abm1122 |
