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The role of root hairs in water uptake: recent advances and future perspectives
Cai, G., & Ahmed, M. A. (2022). The role of root hairs in water uptake: recent advances and future perspectives. Journal of Experimental Botany. https://doi.org/10.1093/jxb/erac114
A scalable strategy to solve structures of PDZ domains and their complexes
Cousido-Siah, A., Carneiro, L., Kostmann, C., Ecsedi, P., Nyitray, L., Trave, G., & Gogl, G. (2022). A scalable strategy to solve structures of PDZ domains and their complexes. Acta Crystallographica Section D: Structural Biology, 78, 509-516. https://doi.org/10.1107/S2059798322001784
Discovery and optimization of highly selective inhibitors of CDK5
Daniels, M. H., Malojcic, G., Clugston, S. L., Williams, B., Coeffet-Le Gal, M., Pan-Zhou, X. R., … Ledeboer, M. (2022). Discovery and optimization of highly selective inhibitors of CDK5. Journal of Medicinal Chemistry, 65(4), 3575-3596. https://doi.org/10.1021/acs.jmedchem.1c02069
Discovery of a Ni<sup>2+</sup>-dependent guanidine hydrolase in bacteria
Funck, D., Sinn, M., Fleming, J. R., Stanoppi, M., Dietrich, J., López-Igual, R., … Hartig, J. S. (2022). Discovery of a Ni2+-dependent guanidine hydrolase in bacteria. Nature, 603(7901), 515-521. https://doi.org/10.1038/s41586-022-04490-x
Discovery of the clinical candidate MAK683: an EED-directed, allosteric, and selective PRC2 inhibitor for the treatment of advanced malignancies
Huang, Y., Sendzik, M., Zhang, J., Gao, Z., Sun, Y., Wang, L., … Oyang, C. (2022). Discovery of the clinical candidate MAK683: an EED-directed, allosteric, and selective PRC2 inhibitor for the treatment of advanced malignancies. Journal of Medicinal Chemistry, 65(7), 5317-5333. https://doi.org/10.1021/acs.jmedchem.1c02148
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors
Lategahn, J., Tumbrink, H. L., Schultz-Fademrecht, C., Heimsoeth, A., Werr, L., Niggenaber, J., … Rauh, D. (2022). Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. Journal of Medicinal Chemistry, 65(9), 6643-6655. https://doi.org/10.1021/acs.jmedchem.1c02080
Atom-by-atom synthesis of multiatom-supported catalytic clusters by liquid-phase atomic layer deposition
Le Monnier, B. P., Savereide, L., Kılıç, M., Schnyder, R., Mensi, M. D., Avalos, C. E., … Luterbacher, J. S. (2022). Atom-by-atom synthesis of multiatom-supported catalytic clusters by liquid-phase atomic layer deposition. ACS Sustainable Chemistry and Engineering, 10(11), 3455-3465. https://doi.org/10.1021/acssuschemeng.1c07056
Oxetane promise delivered: discovery of long-acting IDO1 inhibitors suitable for Q3W oral or parenteral dosing
Li, D., Sloman, D. L., Achab, A., Zhou, H., McGowan, M. A., White, C., … Han, Y. (2022). Oxetane promise delivered: discovery of long-acting IDO1 inhibitors suitable for Q3W oral or parenteral dosing. Journal of Medicinal Chemistry, 65(8), 6001-6016. https://doi.org/10.1021/acs.jmedchem.1c01670
Design, synthesis, and structure-activity relationship optimization of pyrazolopyrimidine amide inhibitors of phosphoinositide 3-kinase <em>γ</em> (PI3K<em>γ</em>)
Mata, G., Miles, D. H., Drew, S. L., Fournier, J., Lawson, K. V., Mailyan, A. K., … Jeffrey, J. L. (2022). Design, synthesis, and structure-activity relationship optimization of pyrazolopyrimidine amide inhibitors of phosphoinositide 3-kinase γ (PI3Kγ). Journal of Medicinal Chemistry, 65(2), 1418-1444. https://doi.org/10.1021/acs.jmedchem.1c01153
TDP-43 Modulation by Tau-Tubulin kinase 1 inhibitors: a new avenue for future amyotrophic lateral sclerosis therapy
Nozal, V., Martínez-González, L., Gomez-Almeria, M., Gonzalo-Consuegra, C., Santana, P., Chaikuad, A., … Martinez, A. (2022). TDP-43 Modulation by Tau-Tubulin kinase 1 inhibitors: a new avenue for future amyotrophic lateral sclerosis therapy. Journal of Medicinal Chemistry, 65(2), 1585-1607. https://doi.org/10.1021/acs.jmedchem.1c01942
Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity
Zeinyeh, W., Esvan, Y. J., Josselin, B., Defois, M., Baratte, B., Knapp, S., … Moreau, P. (2022). Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity. European Journal of Medicinal Chemistry, 236, 114369 (11 pp.). https://doi.org/10.1016/j.ejmech.2022.114369