| Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
Adam, S., Zheng, D., Klein, A., Volz, C., Mullen, W., Shirran, S. L., … Koehnke, J. (2023). Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis. Nature Chemistry, 15(4), 560-568. https://doi.org/10.1038/s41557-023-01153-w |
| Elucidation of the GSK3α structure informs the design of novel, paralog-selective inhibitors
Amaral, B., Capacci, A., Anderson, T., Tezer, C., Bajrami, B., Lulla, M., … Koirala, S. (2023). Elucidation of the GSK3α structure informs the design of novel, paralog-selective inhibitors. ACS Chemical Neuroscience, 14(6), 1080-1094. https://doi.org/10.1021/acschemneuro.2c00476 |
| Turning universal O into rare Bombay type blood
Anso, I., Naegeli, A., Cifuente, J. O., Orrantia, A., Andersson, E., Zenarruzabeitia, O., … Guerin, M. E. (2023). Turning universal O into rare Bombay type blood. Nature Communications, 14(1), 1765 (16 pp.). https://doi.org/10.1038/s41467-023-37324-z |
| Targeting the alternative vitamin E metabolite binding site enables noncanonical PPAR<em>γ</em> modulation
Arifi, S., Marschner, J. A., Pollinger, J., Isigkeit, L., Heitel, P., Kaiser, A., … Merk, D. (2023). Targeting the alternative vitamin E metabolite binding site enables noncanonical PPARγ modulation. Journal of the American Chemical Society, 145(27), 14802-14810. https://doi.org/10.1021/jacs.3c03417 |
| Phosphorus adsorption on iron-coated sand under reducing conditions
Barcala, V., Jansen, S., Gerritse, J., Mangold, S., Voegelin, A., & Behrends, T. (2023). Phosphorus adsorption on iron-coated sand under reducing conditions. Journal of Environmental Quality, 52(1), 74-87. https://doi.org/10.1002/jeq2.20432 |
| Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
Bashore, F. M., Marquez, A. B., Chaikuad, A., Howell, S., Dunn, A. S., Beltran, A. A., … Axtman, A. D. (2023). Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis. Scientific Reports, 13(1), 6118 (17 pp.). https://doi.org/10.1038/s41598-023-32854-4 |
| Structure-based design of inhibitors of the m<sup>6</sup>A-RNA writer enzyme METTL3
Bedi, R. K., Huang, D., Li, Y., & Caflisch, A. (2023). Structure-based design of inhibitors of the m6A-RNA writer enzyme METTL3. ACS Bio & Med Chem Au, 3(4), 359-370. https://doi.org/10.1021/acsbiomedchemau.3c00023 |
| Structure of <em>Leishmania donovani</em> 6-phosphogluconate dehydrogenase and inhibition by phosphine gold(I) complexes: a potential approach to leishmaniasis treatment
Berneburg, I., Stumpf, M., Velten, A. S., Rahlfs, S., Przyborski, J., Becker, K., & Fritz-Wolf, K. (2023). Structure of Leishmania donovani 6-phosphogluconate dehydrogenase and inhibition by phosphine gold(I) complexes: a potential approach to leishmaniasis treatment. International Journal of Molecular Sciences, 24(10), 8615 (20 pp.). https://doi.org/10.3390/ijms24108615 |
| Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition
Billiald, P., Slater, A., Welin, M., Clark, J. C., Loyau, S., Pugnière, M., … Jandrot-Perrus, M. (2023). Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition. Blood Advances, 7(7), 1258-1268. https://doi.org/10.1182/bloodadvances.2022007863 |
| Influence of temperature on the performance of carbon- and ato-supported oxygen evolution reaction catalysts in a gas diffusion electrode setup
Bornet, A., Pittkowski, R., Nielsen, T. M., Berner, E., Maletzko, A., Schröder, J., … Arenz, M. (2023). Influence of temperature on the performance of carbon- and ato-supported oxygen evolution reaction catalysts in a gas diffusion electrode setup. ACS Catalysis, 13(11), 7568-7577. https://doi.org/10.1021/acscatal.3c01193 |
| Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839
Bothe, U., Günther, J., Nubbemeyer, R., Siebeneicher, H., Ring, S., Bömer, U., … Schmidt, N. (2023). Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839. Journal of Medicinal Chemistry, 67, 1125-1242. https://doi.org/10.1021/acs.jmedchem.3c01714 |
| Implications of Ga promotion and metal-oxide interface from tailored PtGa propane dehydrogenation catalysts supported on carbon
Brack, E., Plodinec, M., Willinger, M. G., & Copéret, C. (2023). Implications of Ga promotion and metal-oxide interface from tailored PtGa propane dehydrogenation catalysts supported on carbon. Chemical Science, 14, 12739-12746. https://doi.org/10.1039/d3sc04711c |
| Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
Brkic, A., Leibundgut, M., Jablonska, J., Zanki, V., Car, Z., Petrovic Perokovic, V., … Gruic-Sovulj, I. (2023). Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif. Nature Communications, 14(1), 5498 (12 pp.). https://doi.org/10.1038/s41467-023-41244-3 |
| Nitrogen fixation and hydrogen evolution by sterically encumbered Mo-nitrogenase
Cadoux, C., Ratcliff, D., Maslać, N., Gu, W., Tsakoumagkos, I., Hoogendoorn, S., … Milton, R. D. (2023). Nitrogen fixation and hydrogen evolution by sterically encumbered Mo-nitrogenase. JACS Au, 3(5), 1521-1533. https://doi.org/10.1021/jacsau.3c00165 |
| The mononuclear metal-binding site of Mo-nitrogenase is not required for activity
Cadoux, C., Maslać, N., Di Luzio, L., Ratcliff, D., Gu, W., Wagner, T., & Milton, R. D. (2023). The mononuclear metal-binding site of Mo-nitrogenase is not required for activity. JACS Au, 3(11), 2993-2999. https://doi.org/10.1021/jacsau.3c00567 |
| Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors
Cao, Y., Kümmel, F., Logemann, E., Gebauer, J. M., Lawson, A. W., Yu, D., … Schulze-Lefert, P. (2023). Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors. Proceedings of the National Academy of Sciences of the United States of America PNAS, 120(32), e2307604120 (11 pp.). https://doi.org/10.1073/pnas.2307604120 |
| Fracture in porous bone analysed with a numerical phase-field dynamical model
Carlsson, J., Braesch-Andersen, A., Ferguson, S. J., & Isaksson, P. (2023). Fracture in porous bone analysed with a numerical phase-field dynamical model. Journal of the Mechanical Behavior of Biomedical Materials, 139, 105659 (12 pp.). https://doi.org/10.1016/j.jmbbm.2023.105659 |
| Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome
Chandra, M., Đaković, S., Foti, K., Zeelen, J. P., van Straaten, M., Aresta-Branco, F., … Stebbins, C. E. (2023). Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome. PLoS Neglected Tropical Diseases, 17(2), e0011093 (18 pp.). https://doi.org/10.1371/journal.pntd.0011093 |
| Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity
Chen, X. R., Poudel, L., Hong, Z., Johnen, P., Katti, S., Tripathi, A., … Igumenova, T. I. (2023). Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. Journal of Biological Chemistry, 299(2), 102861 (21 pp.). https://doi.org/10.1016/j.jbc.2022.102861 |
| Multimeric structure of a subfamily III haloalkane dehalogenase‐like enzyme solved by combination of cryo‐EM and x‐ray crystallography
Chmelova, K., Gao, T., Polak, M., Schenkmayerova, A., Croll, T. I., Shaikh, T. R., … Marek, M. (2023). Multimeric structure of a subfamily III haloalkane dehalogenase‐like enzyme solved by combination of cryo‐EM and x‐ray crystallography. Protein Science, 32(10), e4751 (22 pp.). https://doi.org/10.1002/pro.4751 |
