| Structure-based optimization and biological evaluation of potent and selective MMP-7 inhibitors for kidney fibrosis
Abe-Sato, K., Tabuse, H., Kanazawa, H., Kamitani, M., Endo, M., Tokura, S., … Oka, Y. (2023). Structure-based optimization and biological evaluation of potent and selective MMP-7 inhibitors for kidney fibrosis. Journal of Medicinal Chemistry, 66(21), 14653-14668. https://doi.org/10.1021/acs.jmedchem.3c01166 |
| Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
Adam, S., Zheng, D., Klein, A., Volz, C., Mullen, W., Shirran, S. L., … Koehnke, J. (2023). Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis. Nature Chemistry, 15(4), 560-568. https://doi.org/10.1038/s41557-023-01153-w |
| Discovery of the TLR7/8 antagonist MHV370 for treatment of systemic autoimmune diseases
Alper, P., Betschart, C., André, C., Boulay, T., Cheng, D., Deane, J., … Michellys, P. Y. (2023). Discovery of the TLR7/8 antagonist MHV370 for treatment of systemic autoimmune diseases. ACS Medicinal Chemistry Letters, 14(8), 1054-1062. https://doi.org/10.1021/acsmedchemlett.3c00136 |
| Lipid exchange in crystal-confined fatty acid binding proteins: X-ray evidence and molecular dynamics explanation
Alvarez, H. A., Cousido-Siah, A., Espinosa, Y. R., Podjarny, A., Carlevaro, C. M., & Howard, E. (2023). Lipid exchange in crystal-confined fatty acid binding proteins: X-ray evidence and molecular dynamics explanation. Proteins, 91(11), 1525-1534. https://doi.org/10.1002/prot.26546 |
| Elucidation of the GSK3α structure informs the design of novel, paralog-selective inhibitors
Amaral, B., Capacci, A., Anderson, T., Tezer, C., Bajrami, B., Lulla, M., … Koirala, S. (2023). Elucidation of the GSK3α structure informs the design of novel, paralog-selective inhibitors. ACS Chemical Neuroscience, 14(6), 1080-1094. https://doi.org/10.1021/acschemneuro.2c00476 |
| Turning universal O into rare Bombay type blood
Anso, I., Naegeli, A., Cifuente, J. O., Orrantia, A., Andersson, E., Zenarruzabeitia, O., … Guerin, M. E. (2023). Turning universal O into rare Bombay type blood. Nature Communications, 14(1), 1765 (16 pp.). https://doi.org/10.1038/s41467-023-37324-z |
| Targeting the alternative vitamin E metabolite binding site enables noncanonical PPAR<em>γ</em> modulation
Arifi, S., Marschner, J. A., Pollinger, J., Isigkeit, L., Heitel, P., Kaiser, A., … Merk, D. (2023). Targeting the alternative vitamin E metabolite binding site enables noncanonical PPARγ modulation. Journal of the American Chemical Society, 145(27), 14802-14810. https://doi.org/10.1021/jacs.3c03417 |
| Fragment-based discovery of novel VE-PTP inhibitors using orthogonal biophysical techniques
Asano, W., Yamanaka, K., Ohara, Y., Uhara, T., Doi, S., Orita, T., … Hantani, Y. (2023). Fragment-based discovery of novel VE-PTP inhibitors using orthogonal biophysical techniques. Biochemistry, 62(14), 2161-2169. https://doi.org/10.1021/acs.biochem.3c00079 |
| Light-driven C–O coupling of carboxylic acids and alkyl halides over a Ni single-atom catalyst
Bajada, M. A., Di Liberto, G., Tosoni, S., Ruta, V., Mino, L., Allasia, N., … Vilé, G. (2023). Light-driven C–O coupling of carboxylic acids and alkyl halides over a Ni single-atom catalyst. Nature Synthesis, 2, 1092-1103. https://doi.org/10.1038/s44160-023-00341-3 |
| Development of a potent cyclic peptide inhibitor of the nNOS/PSD-95 interaction
Balboa, J. R., Essig, D. J., Ma, S., Karer, N., Clemmensen, L. S., Pedersen, S. W., … Strømgaard, K. (2023). Development of a potent cyclic peptide inhibitor of the nNOS/PSD-95 interaction. Journal of Medicinal Chemistry, 66(1), 976-990. https://doi.org/10.1021/acs.jmedchem.2c01803 |
| Synthesis of thieno[2,3-<em>c</em>]pyridine derived GRK2 inhibitors
Balo, T., Sapi, A., Kiss, A., Raimbaud, E., Paysant, J., Cattin, M. E., … Faucher, N. (2023). Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors. Monatshefte für Chemie, 154, 1339-1357. https://doi.org/10.1007/s00706-021-02889-2 |
| Phosphorus adsorption on iron-coated sand under reducing conditions
Barcala, V., Jansen, S., Gerritse, J., Mangold, S., Voegelin, A., & Behrends, T. (2023). Phosphorus adsorption on iron-coated sand under reducing conditions. Journal of Environmental Quality, 52(1), 74-87. https://doi.org/10.1002/jeq2.20432 |
| Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
Bashore, F. M., Marquez, A. B., Chaikuad, A., Howell, S., Dunn, A. S., Beltran, A. A., … Axtman, A. D. (2023). Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis. Scientific Reports, 13(1), 6118 (17 pp.). https://doi.org/10.1038/s41598-023-32854-4 |
| Structure-based design of inhibitors of the m<sup>6</sup>A-RNA writer enzyme METTL3
Bedi, R. K., Huang, D., Li, Y., & Caflisch, A. (2023). Structure-based design of inhibitors of the m6A-RNA writer enzyme METTL3. ACS Bio & Med Chem Au, 3(4), 359-370. https://doi.org/10.1021/acsbiomedchemau.3c00023 |
| Structure of <em>Leishmania donovani</em> 6-phosphogluconate dehydrogenase and inhibition by phosphine gold(I) complexes: a potential approach to leishmaniasis treatment
Berneburg, I., Stumpf, M., Velten, A. S., Rahlfs, S., Przyborski, J., Becker, K., & Fritz-Wolf, K. (2023). Structure of Leishmania donovani 6-phosphogluconate dehydrogenase and inhibition by phosphine gold(I) complexes: a potential approach to leishmaniasis treatment. International Journal of Molecular Sciences, 24(10), 8615 (20 pp.). https://doi.org/10.3390/ijms24108615 |
| Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition
Billiald, P., Slater, A., Welin, M., Clark, J. C., Loyau, S., Pugnière, M., … Jandrot-Perrus, M. (2023). Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition. Blood Advances, 7(7), 1258-1268. https://doi.org/10.1182/bloodadvances.2022007863 |
| Identification of M4205 - a highly selective inhibitor of KIT mutations for treatment of unresectable metastatic or recurrent gastrointestinal stromal tumors
Blum, A., Dorsch, D., Linde, N., Brandstetter, S., Buchstaller, H. P., Busch, M., … Esdar, C. (2023). Identification of M4205 - a highly selective inhibitor of KIT mutations for treatment of unresectable metastatic or recurrent gastrointestinal stromal tumors. Journal of Medicinal Chemistry, 66(4), 2386-2395. https://doi.org/10.1021/acs.jmedchem.2c00851 |
| Influence of temperature on the performance of carbon- and ato-supported oxygen evolution reaction catalysts in a gas diffusion electrode setup
Bornet, A., Pittkowski, R., Nielsen, T. M., Berner, E., Maletzko, A., Schröder, J., … Arenz, M. (2023). Influence of temperature on the performance of carbon- and ato-supported oxygen evolution reaction catalysts in a gas diffusion electrode setup. ACS Catalysis, 13(11), 7568-7577. https://doi.org/10.1021/acscatal.3c01193 |
| Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839
Bothe, U., Günther, J., Nubbemeyer, R., Siebeneicher, H., Ring, S., Bömer, U., … Schmidt, N. (2023). Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839. Journal of Medicinal Chemistry, 67, 1125-1242. https://doi.org/10.1021/acs.jmedchem.3c01714 |
| Implications of Ga promotion and metal-oxide interface from tailored PtGa propane dehydrogenation catalysts supported on carbon
Brack, E., Plodinec, M., Willinger, M. G., & Copéret, C. (2023). Implications of Ga promotion and metal-oxide interface from tailored PtGa propane dehydrogenation catalysts supported on carbon. Chemical Science, 14, 12739-12746. https://doi.org/10.1039/d3sc04711c |
