| Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
Adam, S., Zheng, D., Klein, A., Volz, C., Mullen, W., Shirran, S. L., … Koehnke, J. (2023). Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis. Nature Chemistry, 15(4), 560-568. https://doi.org/10.1038/s41557-023-01153-w |
| Discovery of the TLR7/8 antagonist MHV370 for treatment of systemic autoimmune diseases
Alper, P., Betschart, C., André, C., Boulay, T., Cheng, D., Deane, J., … Michellys, P. Y. (2023). Discovery of the TLR7/8 antagonist MHV370 for treatment of systemic autoimmune diseases. ACS Medicinal Chemistry Letters, 14(8), 1054-1062. https://doi.org/10.1021/acsmedchemlett.3c00136 |
| Elucidation of the GSK3α structure informs the design of novel, paralog-selective inhibitors
Amaral, B., Capacci, A., Anderson, T., Tezer, C., Bajrami, B., Lulla, M., … Koirala, S. (2023). Elucidation of the GSK3α structure informs the design of novel, paralog-selective inhibitors. ACS Chemical Neuroscience, 14(6), 1080-1094. https://doi.org/10.1021/acschemneuro.2c00476 |
| Turning universal O into rare Bombay type blood
Anso, I., Naegeli, A., Cifuente, J. O., Orrantia, A., Andersson, E., Zenarruzabeitia, O., … Guerin, M. E. (2023). Turning universal O into rare Bombay type blood. Nature Communications, 14(1), 1765 (16 pp.). https://doi.org/10.1038/s41467-023-37324-z |
| Targeting the alternative vitamin E metabolite binding site enables noncanonical PPAR<em>γ</em> modulation
Arifi, S., Marschner, J. A., Pollinger, J., Isigkeit, L., Heitel, P., Kaiser, A., … Merk, D. (2023). Targeting the alternative vitamin E metabolite binding site enables noncanonical PPARγ modulation. Journal of the American Chemical Society, 145(27), 14802-14810. https://doi.org/10.1021/jacs.3c03417 |
| Development of a potent cyclic peptide inhibitor of the nNOS/PSD-95 interaction
Balboa, J. R., Essig, D. J., Ma, S., Karer, N., Clemmensen, L. S., Pedersen, S. W., … Strømgaard, K. (2023). Development of a potent cyclic peptide inhibitor of the nNOS/PSD-95 interaction. Journal of Medicinal Chemistry, 66(1), 976-990. https://doi.org/10.1021/acs.jmedchem.2c01803 |
| Phosphorus adsorption on iron-coated sand under reducing conditions
Barcala, V., Jansen, S., Gerritse, J., Mangold, S., Voegelin, A., & Behrends, T. (2023). Phosphorus adsorption on iron-coated sand under reducing conditions. Journal of Environmental Quality, 52(1), 74-87. https://doi.org/10.1002/jeq2.20432 |
| Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
Bashore, F. M., Marquez, A. B., Chaikuad, A., Howell, S., Dunn, A. S., Beltran, A. A., … Axtman, A. D. (2023). Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis. Scientific Reports, 13(1), 6118 (17 pp.). https://doi.org/10.1038/s41598-023-32854-4 |
| Structure-based design of inhibitors of the m<sup>6</sup>A-RNA writer enzyme METTL3
Bedi, R. K., Huang, D., Li, Y., & Caflisch, A. (2023). Structure-based design of inhibitors of the m6A-RNA writer enzyme METTL3. ACS Bio & Med Chem Au, 3(4), 359-370. https://doi.org/10.1021/acsbiomedchemau.3c00023 |
| Structure of <em>Leishmania donovani</em> 6-phosphogluconate dehydrogenase and inhibition by phosphine gold(I) complexes: a potential approach to leishmaniasis treatment
Berneburg, I., Stumpf, M., Velten, A. S., Rahlfs, S., Przyborski, J., Becker, K., & Fritz-Wolf, K. (2023). Structure of Leishmania donovani 6-phosphogluconate dehydrogenase and inhibition by phosphine gold(I) complexes: a potential approach to leishmaniasis treatment. International Journal of Molecular Sciences, 24(10), 8615 (20 pp.). https://doi.org/10.3390/ijms24108615 |
| Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition
Billiald, P., Slater, A., Welin, M., Clark, J. C., Loyau, S., Pugnière, M., … Jandrot-Perrus, M. (2023). Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition. Blood Advances, 7(7), 1258-1268. https://doi.org/10.1182/bloodadvances.2022007863 |
| Identification of M4205 - a highly selective inhibitor of KIT mutations for treatment of unresectable metastatic or recurrent gastrointestinal stromal tumors
Blum, A., Dorsch, D., Linde, N., Brandstetter, S., Buchstaller, H. P., Busch, M., … Esdar, C. (2023). Identification of M4205 - a highly selective inhibitor of KIT mutations for treatment of unresectable metastatic or recurrent gastrointestinal stromal tumors. Journal of Medicinal Chemistry, 66(4), 2386-2395. https://doi.org/10.1021/acs.jmedchem.2c00851 |
| Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
Brkic, A., Leibundgut, M., Jablonska, J., Zanki, V., Car, Z., Petrovic Perokovic, V., … Gruic-Sovulj, I. (2023). Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif. Nature Communications, 14(1), 5498 (12 pp.). https://doi.org/10.1038/s41467-023-41244-3 |
| Discovery of cycloalkyl[<em>c</em>]thiophenes as novel scaffolds for hypoxia-inducible factor-2<em>α</em> inhibitors
Buchstaller, H. P., Sala-Hojman, A., Leiendecker, M., Albers, J., Anlauf, U., Berges, N., … Zarębski, A. (2023). Discovery of cycloalkyl[c]thiophenes as novel scaffolds for hypoxia-inducible factor-2α inhibitors. Journal of Medicinal Chemistry, 66(13), 8666-8686. https://doi.org/10.1021/acs.jmedchem.3c00332 |
| Oxygen-induced chromophore degradation in the photoswitchable red fluorescent protein rsCherry
Bui, T. Y. H., De Zitter, E., Moeyaert, B., Pecqueur, L., Srinivasu, B. Y., Economou, A., … Pedre, B. (2023). Oxygen-induced chromophore degradation in the photoswitchable red fluorescent protein rsCherry. International Journal of Biological Macromolecules, 239, 124179 (9 pp.). https://doi.org/10.1016/j.ijbiomac.2023.124179 |
| Structural and functional characterization of the ureidoacrylate amidohydrolase RutB from <em>Escherichia coli</em>
Busch, M. R., Rajendran, C., & Sterner, R. (2023). Structural and functional characterization of the ureidoacrylate amidohydrolase RutB from Escherichia coli. Biochemistry, 62(3), 863-872. https://doi.org/10.1021/acs.biochem.2c00640 |
| FRAGTORY: pharmacophore-focused design, synthesis, and evaluation of an sp<sup>3</sup>-enriched fragment library
Bührmann, M., Kallepu, S., Warmuth, J. D., Wiese, J. N., Ehrt, C., Vatheuer, H., … Rauh, D. (2023). FRAGTORY: pharmacophore-focused design, synthesis, and evaluation of an sp3-enriched fragment library. Journal of Medicinal Chemistry, 66(9), 6297-6314. https://doi.org/10.1021/acs.jmedchem.3c00187 |
| Nitrogen fixation and hydrogen evolution by sterically encumbered Mo-nitrogenase
Cadoux, C., Ratcliff, D., Maslać, N., Gu, W., Tsakoumagkos, I., Hoogendoorn, S., … Milton, R. D. (2023). Nitrogen fixation and hydrogen evolution by sterically encumbered Mo-nitrogenase. JACS Au, 3(5), 1521-1533. https://doi.org/10.1021/jacsau.3c00165 |
| Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors
Cao, Y., Kümmel, F., Logemann, E., Gebauer, J. M., Lawson, A. W., Yu, D., … Schulze-Lefert, P. (2023). Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors. Proceedings of the National Academy of Sciences of the United States of America PNAS, 120(32), e2307604120 (11 pp.). https://doi.org/10.1073/pnas.2307604120 |
| Fracture in porous bone analysed with a numerical phase-field dynamical model
Carlsson, J., Braesch-Andersen, A., Ferguson, S. J., & Isaksson, P. (2023). Fracture in porous bone analysed with a numerical phase-field dynamical model. Journal of the Mechanical Behavior of Biomedical Materials, 139, 105659 (12 pp.). https://doi.org/10.1016/j.jmbbm.2023.105659 |
