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Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters
Aksu, M., Kumar, P., Güttler, T., Taxer, W., Gregor, K., Mußil, B., … Görlich, D. (2024). Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Research, 221, 105778 (21 pp.). https://doi.org/10.1016/j.antiviral.2023.105778
Heterometallic transition metal oxides containing lewis acids as molecular catalysts for the reduction of carbon dioxide to carbon monoxide with bimodal activity
Azaiza-Dabbah, D., Wang, F., Haddad, E., Solé-Daura, A., Carmieli, R., Poblet, J. M., … Neumann, R. (2024). Heterometallic transition metal oxides containing lewis acids as molecular catalysts for the reduction of carbon dioxide to carbon monoxide with bimodal activity. Journal of the American Chemical Society, 146(40), 27871-27885. https://doi.org/10.1021/jacs.4c10412
Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
Balourdas, D. I., Markl, A. M., Krämer, A., Settanni, G., & Joerger, A. C. (2024). Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators. Cell Death & Disease, 15(6), 408. https://doi.org/10.1038/s41419-024-06739-x
Discovery and structural characterization of a thermostable bacterial monoamine oxidase
Basile, L., Santema, L. L., Binda, C., & Fraaije, M. W. (2024). Discovery and structural characterization of a thermostable bacterial monoamine oxidase. FEBS Journal, 291, 849-864. https://doi.org/10.1111/febs.16973
Viral peptide conjugates for metal-warhead delivery to chromatin
Batchelor, L. K., De Falco, L., Dyson, P. J., & Davey, C. A. (2024). Viral peptide conjugates for metal-warhead delivery to chromatin. RSC Advances, 14(13), 8718-8725. https://doi.org/10.1039/d4ra01617c
Metadynamics simulations reveal alloying-dealloying processes for bimetallic PdGa nanoparticles under CO<sub>2</sub> hydrogenation
Baumgärtner, J. F., Müller, A., Docherty, S. R., Comas-Vives, A., Payard, P. A., & Copéret, C. (2024). Metadynamics simulations reveal alloying-dealloying processes for bimetallic PdGa nanoparticles under CO2 hydrogenation. Chemical Science, 15, 4871-4880. https://doi.org/10.1039/d4sc00484a
Probing protein-ligand methyl−π interaction geometries through chemical shift measurements of selectively labeled methyl groups
Beier, A., Platzer, G., Höfurthner, T., Ptaszek, A. L., Lichtenecker, R. J., Geist, L., … Konrat, R. (2024). Probing protein-ligand methyl−π interaction geometries through chemical shift measurements of selectively labeled methyl groups. Journal of Medicinal Chemistry, 67(15), 13187-13196. https://doi.org/10.1021/acs.jmedchem.4c01128
Primordial magnetotaxis in putative giant paleoproterozoic magnetofossils
Bellon, U. D., Williams, W., Trindade, R. I. F., Maldanis, L., & Galante, D. (2024). Primordial magnetotaxis in putative giant paleoproterozoic magnetofossils. Proceedings of the National Academy of Sciences of the United States of America PNAS, 121(23), e2319148121 (10 pp.). https://doi.org/10.1073/pnas.2319148121
Impact of nickel on iridium–ruthenium structure and activity for the oxygen evolution reaction under acidic conditions
Bertheussen, E., Pitscheider, S., Cooper, S. R., Pittkowski, R., Svane, K. L., Bornet, A., … Pedersen, C. M. (2024). Impact of nickel on iridium–ruthenium structure and activity for the oxygen evolution reaction under acidic conditions. ACS Materials Au, 4(5), 512-522. https://doi.org/10.1021/acsmaterialsau.4c00025
Impact of Cu<sup>+</sup> and Cu<sup>2+</sup> species on the oxide-metal transition processes of Cu<sub>x</sub>O foams during the CO<sub>2</sub>RR probed by operando Quick-XAS
Blaseio, S., Dosche, C., Rahaman, M., Kiran, K., Dworzak, A., Mahrt, B., … Oezaslan, M. (2024). Impact of Cu+ and Cu2+ species on the oxide-metal transition processes of CuxO foams during the CO2RR probed by operando Quick-XAS. Journal of Materials Chemistry A, 12(41), 28177-28192. https://doi.org/10.1039/d4ta02217c
High-resolution vision in pelagic polychaetes
Bok, M. J., Macali, A., & Garm, A. (2024). High-resolution vision in pelagic polychaetes. Current Biology, 34(7), R269-R270. https://doi.org/10.1016/j.cub.2024.02.055
Discovery of IRAK4 inhibitors BAY1834845 (zabedosertib) and BAY1830839
Bothe, U., Günther, J., Nubbemeyer, R., Siebeneicher, H., Ring, S., Bömer, U., … Schmidt, N. (2024). Discovery of IRAK4 inhibitors BAY1834845 (zabedosertib) and BAY1830839. Journal of Medicinal Chemistry, 67, 1225-1242. https://doi.org/10.1021/acs.jmedchem.3c01714
1,4-pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile
Buffa, V., Meyners, C., Sugiarto, W. O., Bauder, M., Gaali, S., & Hausch, F. (2024). 1,4-pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. ChemMedChem, 19(17), e202400264 (23 pp.). https://doi.org/10.1002/cmdc.202400264
Ligandability assessment of the C-terminal Rel-homology domain of NFAT1
Böttcher, J., Fuchs, J. E., Mayer, M., Kahmann, J., Zak, K. M., Wunberg, T., … Kessler, D. (2024). Ligandability assessment of the C-terminal Rel-homology domain of NFAT1. Archiv der Pharmazie, 357(6), 2300649 (7 pp.). https://doi.org/10.1002/ardp.202300649
Structural comparison of (hyper-)thermophilic nitrogenase reductases from three marine <em>Methanococcales</em>
Cadoux, C., Maslać, N., Bolte, P., Murken, F., Gu, W., Milton, R. D., & Wagner, T. (2024). Structural comparison of (hyper-)thermophilic nitrogenase reductases from three marine Methanococcales. FEBS Journal, 291(15), 3454-3480. https://doi.org/10.1111/febs.17148
Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity
Carney, D. W., Leffler, A. E., Bell, J. A., Chandrasinghe, A. S., Cheng, C., Chang, E., … Vafaei, S. (2024). Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity. Bioorganic and Medicinal Chemistry, 103, 117577 (27 pp.). https://doi.org/10.1016/j.bmc.2023.117577
Tetrahydropyridine LIMK inhibitors: structure activity studies and biological characterization
Champiré, A., Berabez, R., Braka, A., Cosson, A., Corret, J., Girardin, C., … Routier, S. (2024). Tetrahydropyridine LIMK inhibitors: structure activity studies and biological characterization. European Journal of Medicinal Chemistry, 271, 116391 (27 pp.). https://doi.org/10.1016/j.ejmech.2024.116391
Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers
Chapeau, E. A., Sansregret, L., Galli, G. G., Chène, P., Wartmann, M., Mourikis, T. P., … Schmelzle, T. (2024). Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers. Nature Cancer, 5(7), 1102-1120. https://doi.org/10.1038/s43018-024-00754-9
Conserved proline residues prevent dimerization and aggregation in the β‐lactamase BlaC
Chikunova, A., Manley, M. P., Heijjer, C. N., Drenth, C. S., Cramer‐Blok, A. J., Ahmad, M. U. D., … Ubbink, M. (2024). Conserved proline residues prevent dimerization and aggregation in the β‐lactamase BlaC. Protein Science, 33(4). https://doi.org/10.1002/pro.4972
A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding
Dhamotharan, K., Korn, S. M., Wacker, A., Becker, M. A., Günther, S., Schwalbe, H., & Schlundt, A. (2024). A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding. Nature Communications, 15(1), 10656 (16 pp.). https://doi.org/10.1038/s41467-024-55024-0
 

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