| Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters
Aksu, M., Kumar, P., Güttler, T., Taxer, W., Gregor, K., Mußil, B., … Görlich, D. (2024). Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Research, 221, 105778 (21 pp.). https://doi.org/10.1016/j.antiviral.2023.105778 |
| Heterometallic transition metal oxides containing lewis acids as molecular catalysts for the reduction of carbon dioxide to carbon monoxide with bimodal activity
Azaiza-Dabbah, D., Wang, F., Haddad, E., Solé-Daura, A., Carmieli, R., Poblet, J. M., … Neumann, R. (2024). Heterometallic transition metal oxides containing lewis acids as molecular catalysts for the reduction of carbon dioxide to carbon monoxide with bimodal activity. Journal of the American Chemical Society, 146(40), 27871-27885. https://doi.org/10.1021/jacs.4c10412 |
| Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
Balourdas, D. I., Markl, A. M., Krämer, A., Settanni, G., & Joerger, A. C. (2024). Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators. Cell Death & Disease, 15(6), 408. https://doi.org/10.1038/s41419-024-06739-x |
| Discovery and structural characterization of a thermostable bacterial monoamine oxidase
Basile, L., Santema, L. L., Binda, C., & Fraaije, M. W. (2024). Discovery and structural characterization of a thermostable bacterial monoamine oxidase. FEBS Journal, 291, 849-864. https://doi.org/10.1111/febs.16973 |
| Viral peptide conjugates for metal-warhead delivery to chromatin
Batchelor, L. K., De Falco, L., Dyson, P. J., & Davey, C. A. (2024). Viral peptide conjugates for metal-warhead delivery to chromatin. RSC Advances, 14(13), 8718-8725. https://doi.org/10.1039/d4ra01617c |
| Metadynamics simulations reveal alloying-dealloying processes for bimetallic PdGa nanoparticles under CO<sub>2</sub> hydrogenation
Baumgärtner, J. F., Müller, A., Docherty, S. R., Comas-Vives, A., Payard, P. A., & Copéret, C. (2024). Metadynamics simulations reveal alloying-dealloying processes for bimetallic PdGa nanoparticles under CO2 hydrogenation. Chemical Science, 15, 4871-4880. https://doi.org/10.1039/d4sc00484a |
| Probing protein-ligand methyl−π interaction geometries through chemical shift measurements of selectively labeled methyl groups
Beier, A., Platzer, G., Höfurthner, T., Ptaszek, A. L., Lichtenecker, R. J., Geist, L., … Konrat, R. (2024). Probing protein-ligand methyl−π interaction geometries through chemical shift measurements of selectively labeled methyl groups. Journal of Medicinal Chemistry, 67(15), 13187-13196. https://doi.org/10.1021/acs.jmedchem.4c01128 |
| Primordial magnetotaxis in putative giant paleoproterozoic magnetofossils
Bellon, U. D., Williams, W., Trindade, R. I. F., Maldanis, L., & Galante, D. (2024). Primordial magnetotaxis in putative giant paleoproterozoic magnetofossils. Proceedings of the National Academy of Sciences of the United States of America PNAS, 121(23), e2319148121 (10 pp.). https://doi.org/10.1073/pnas.2319148121 |
| Impact of nickel on iridium–ruthenium structure and activity for the oxygen evolution reaction under acidic conditions
Bertheussen, E., Pitscheider, S., Cooper, S. R., Pittkowski, R., Svane, K. L., Bornet, A., … Pedersen, C. M. (2024). Impact of nickel on iridium–ruthenium structure and activity for the oxygen evolution reaction under acidic conditions. ACS Materials Au, 4(5), 512-522. https://doi.org/10.1021/acsmaterialsau.4c00025 |
| Impact of Cu<sup>+</sup> and Cu<sup>2+</sup> species on the oxide-metal transition processes of Cu<sub>x</sub>O foams during the CO<sub>2</sub>RR probed by operando Quick-XAS
Blaseio, S., Dosche, C., Rahaman, M., Kiran, K., Dworzak, A., Mahrt, B., … Oezaslan, M. (2024). Impact of Cu+ and Cu2+ species on the oxide-metal transition processes of CuxO foams during the CO2RR probed by operando Quick-XAS. Journal of Materials Chemistry A, 12(41), 28177-28192. https://doi.org/10.1039/d4ta02217c |
| High-resolution vision in pelagic polychaetes
Bok, M. J., Macali, A., & Garm, A. (2024). High-resolution vision in pelagic polychaetes. Current Biology, 34(7), R269-R270. https://doi.org/10.1016/j.cub.2024.02.055 |
| Discovery of IRAK4 inhibitors BAY1834845 (zabedosertib) and BAY1830839
Bothe, U., Günther, J., Nubbemeyer, R., Siebeneicher, H., Ring, S., Bömer, U., … Schmidt, N. (2024). Discovery of IRAK4 inhibitors BAY1834845 (zabedosertib) and BAY1830839. Journal of Medicinal Chemistry, 67, 1225-1242. https://doi.org/10.1021/acs.jmedchem.3c01714 |
| 1,4-pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile
Buffa, V., Meyners, C., Sugiarto, W. O., Bauder, M., Gaali, S., & Hausch, F. (2024). 1,4-pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. ChemMedChem, 19(17), e202400264 (23 pp.). https://doi.org/10.1002/cmdc.202400264 |
| Ligandability assessment of the C-terminal Rel-homology domain of NFAT1
Böttcher, J., Fuchs, J. E., Mayer, M., Kahmann, J., Zak, K. M., Wunberg, T., … Kessler, D. (2024). Ligandability assessment of the C-terminal Rel-homology domain of NFAT1. Archiv der Pharmazie, 357(6), 2300649 (7 pp.). https://doi.org/10.1002/ardp.202300649 |
| Structural comparison of (hyper-)thermophilic nitrogenase reductases from three marine <em>Methanococcales</em>
Cadoux, C., Maslać, N., Bolte, P., Murken, F., Gu, W., Milton, R. D., & Wagner, T. (2024). Structural comparison of (hyper-)thermophilic nitrogenase reductases from three marine Methanococcales. FEBS Journal, 291(15), 3454-3480. https://doi.org/10.1111/febs.17148 |
| Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity
Carney, D. W., Leffler, A. E., Bell, J. A., Chandrasinghe, A. S., Cheng, C., Chang, E., … Vafaei, S. (2024). Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity. Bioorganic and Medicinal Chemistry, 103, 117577 (27 pp.). https://doi.org/10.1016/j.bmc.2023.117577 |
| Tetrahydropyridine LIMK inhibitors: structure activity studies and biological characterization
Champiré, A., Berabez, R., Braka, A., Cosson, A., Corret, J., Girardin, C., … Routier, S. (2024). Tetrahydropyridine LIMK inhibitors: structure activity studies and biological characterization. European Journal of Medicinal Chemistry, 271, 116391 (27 pp.). https://doi.org/10.1016/j.ejmech.2024.116391 |
| Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers
Chapeau, E. A., Sansregret, L., Galli, G. G., Chène, P., Wartmann, M., Mourikis, T. P., … Schmelzle, T. (2024). Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers. Nature Cancer, 5(7), 1102-1120. https://doi.org/10.1038/s43018-024-00754-9 |
| Conserved proline residues prevent dimerization and aggregation in the β‐lactamase BlaC
Chikunova, A., Manley, M. P., Heijjer, C. N., Drenth, C. S., Cramer‐Blok, A. J., Ahmad, M. U. D., … Ubbink, M. (2024). Conserved proline residues prevent dimerization and aggregation in the β‐lactamase BlaC. Protein Science, 33(4). https://doi.org/10.1002/pro.4972 |
| A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding
Dhamotharan, K., Korn, S. M., Wacker, A., Becker, M. A., Günther, S., Schwalbe, H., & Schlundt, A. (2024). A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding. Nature Communications, 15(1), 10656 (16 pp.). https://doi.org/10.1038/s41467-024-55024-0 |