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Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters
Aksu, M., Kumar, P., Güttler, T., Taxer, W., Gregor, K., Mußil, B., … Görlich, D. (2024). Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Research, 221, 105778 (21 pp.). https://doi.org/10.1016/j.antiviral.2023.105778
Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
Amrhein, J. A., Berger, L. M., Balourdas, D. I., Joerger, A. C., Menge, A., Krämer, A., … Hanke, T. (2024). Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3. Journal of Medicinal Chemistry, 67(1), 674-690. https://doi.org/10.1021/acs.jmedchem.3c01980
Development of a series of pyrrolopyridone MAT2A inhibitors
Atkinson, S. J., Bagal, S. K., Argyrou, A., Askin, S., Cheung, T., Chiarparin, E., … Williamson, B. (2024). Development of a series of pyrrolopyridone MAT2A inhibitors. Journal of Medicinal Chemistry, 67(6), 4541-4559. https://doi.org/10.1021/acs.jmedchem.3c01860
Heterometallic transition metal oxides containing lewis acids as molecular catalysts for the reduction of carbon dioxide to carbon monoxide with bimodal activity
Azaiza-Dabbah, D., Wang, F., Haddad, E., Solé-Daura, A., Carmieli, R., Poblet, J. M., … Neumann, R. (2024). Heterometallic transition metal oxides containing lewis acids as molecular catalysts for the reduction of carbon dioxide to carbon monoxide with bimodal activity. Journal of the American Chemical Society, 146(40), 27871-27885. https://doi.org/10.1021/jacs.4c10412
Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
Balourdas, D. I., Markl, A. M., Krämer, A., Settanni, G., & Joerger, A. C. (2024). Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators. Cell Death & Disease, 15(6), 408. https://doi.org/10.1038/s41419-024-06739-x
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
Baltgalvis, K. A., Lamb, K. N., Symons, K. T., Wu, C. C., Hoffman, M. A., Snead, A. N., … Kinsella, T. M. (2024). Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature, 629(8011), 435-442. https://doi.org/10.1038/s41586-024-07318-y
Discovery and structural characterization of a thermostable bacterial monoamine oxidase
Basile, L., Santema, L. L., Binda, C., & Fraaije, M. W. (2024). Discovery and structural characterization of a thermostable bacterial monoamine oxidase. FEBS Journal, 291, 849-864. https://doi.org/10.1111/febs.16973
Viral peptide conjugates for metal-warhead delivery to chromatin
Batchelor, L. K., De Falco, L., Dyson, P. J., & Davey, C. A. (2024). Viral peptide conjugates for metal-warhead delivery to chromatin. RSC Advances, 14(13), 8718-8725. https://doi.org/10.1039/d4ra01617c
Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization
Bauer, N., Balourdas, D. I., Schneider, J. R., Zhang, X., Berger, L. M., Berger, B. T., … Joerger, A. C. (2024). Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization. ACS Chemical Biology, 19(2), 266-279. https://doi.org/10.1021/acschembio.3c00427
Metadynamics simulations reveal alloying-dealloying processes for bimetallic PdGa nanoparticles under CO<sub>2</sub> hydrogenation
Baumgärtner, J. F., Müller, A., Docherty, S. R., Comas-Vives, A., Payard, P. A., & Copéret, C. (2024). Metadynamics simulations reveal alloying-dealloying processes for bimetallic PdGa nanoparticles under CO2 hydrogenation. Chemical Science, 15, 4871-4880. https://doi.org/10.1039/d4sc00484a
Probing protein-ligand methyl−π interaction geometries through chemical shift measurements of selectively labeled methyl groups
Beier, A., Platzer, G., Höfurthner, T., Ptaszek, A. L., Lichtenecker, R. J., Geist, L., … Konrat, R. (2024). Probing protein-ligand methyl−π interaction geometries through chemical shift measurements of selectively labeled methyl groups. Journal of Medicinal Chemistry, 67(15), 13187-13196. https://doi.org/10.1021/acs.jmedchem.4c01128
Primordial magnetotaxis in putative giant paleoproterozoic magnetofossils
Bellon, U. D., Williams, W., Trindade, R. I. F., Maldanis, L., & Galante, D. (2024). Primordial magnetotaxis in putative giant paleoproterozoic magnetofossils. Proceedings of the National Academy of Sciences of the United States of America PNAS, 121(23), e2319148121 (10 pp.). https://doi.org/10.1073/pnas.2319148121
PROTACs targeting BRM (SMARCA2) afford selective <em>In vivo</em> degradation over BRG1 (SMARCA4) and are active in BRG1 mutant xenograft tumor models
Berlin, M., Cantley, J., Bookbinder, M., Bortolon, E., Broccatelli, F., Cadelina, G., … Dragovich, P. S. (2024). PROTACs targeting BRM (SMARCA2) afford selective In vivo degradation over BRG1 (SMARCA4) and are active in BRG1 mutant xenograft tumor models. Journal of Medicinal Chemistry, 67, 1262-1313. https://doi.org/10.1021/acs.jmedchem.3c01781
Impact of nickel on iridium–ruthenium structure and activity for the oxygen evolution reaction under acidic conditions
Bertheussen, E., Pitscheider, S., Cooper, S. R., Pittkowski, R., Svane, K. L., Bornet, A., … Pedersen, C. M. (2024). Impact of nickel on iridium–ruthenium structure and activity for the oxygen evolution reaction under acidic conditions. ACS Materials Au, 4(5), 512-522. https://doi.org/10.1021/acsmaterialsau.4c00025
Impact of Cu<sup>+</sup> and Cu<sup>2+</sup> species on the oxide-metal transition processes of Cu<sub>x</sub>O foams during the CO<sub>2</sub>RR probed by operando Quick-XAS
Blaseio, S., Dosche, C., Rahaman, M., Kiran, K., Dworzak, A., Mahrt, B., … Oezaslan, M. (2024). Impact of Cu+ and Cu2+ species on the oxide-metal transition processes of CuxO foams during the CO2RR probed by operando Quick-XAS. Journal of Materials Chemistry A, 12(41), 28177-28192. https://doi.org/10.1039/d4ta02217c
High-resolution vision in pelagic polychaetes
Bok, M. J., Macali, A., & Garm, A. (2024). High-resolution vision in pelagic polychaetes. Current Biology, 34(7), R269-R270. https://doi.org/10.1016/j.cub.2024.02.055
A tiny pocket packs a punch: leveraging pyridones for the discovery of CNS-penetrant aza-indazole IRAK4 inhibitors
Bolduc, P. N., Pfaffenbach, M., Evans, R., Xin, Z., Henry, K. L., Gao, F., … Peterson, E. A. (2024). A tiny pocket packs a punch: leveraging pyridones for the discovery of CNS-penetrant aza-indazole IRAK4 inhibitors. ACS Medicinal Chemistry Letters, 15(5), 714-721. https://doi.org/10.1021/acsmedchemlett.4c00102
Discovery of IRAK4 inhibitors BAY1834845 (zabedosertib) and BAY1830839
Bothe, U., Günther, J., Nubbemeyer, R., Siebeneicher, H., Ring, S., Bömer, U., … Schmidt, N. (2024). Discovery of IRAK4 inhibitors BAY1834845 (zabedosertib) and BAY1830839. Journal of Medicinal Chemistry, 67, 1225-1242. https://doi.org/10.1021/acs.jmedchem.3c01714
Evolution-inspired engineering of nonribosomal peptide synthetases
Bozhüyük, K. A. J., Präve, L., Kegler, C., Schenk, L., Kaiser, S., Schelhas, C., … Bode, H. B. (2024). Evolution-inspired engineering of nonribosomal peptide synthetases. Science, 383(6689), eadg4320 (11 pp.). https://doi.org/10.1126/science.adg4320
A novel <em>O-</em> and <em>S</em>-methyltransferase from <em>Pleurotus </em>sapidus is involved in flavor formation
Brescia, F. F., Korf, L., Essen, L. O., Zorn, H., & Ruehl, M. (2024). A novel O- and S-methyltransferase from Pleurotus sapidus is involved in flavor formation. Journal of Agricultural and Food Chemistry, 72(12), 6471-6480. https://doi.org/10.1021/acs.jafc.3c08849
 

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