| Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters
Aksu, M., Kumar, P., Güttler, T., Taxer, W., Gregor, K., Mußil, B., … Görlich, D. (2024). Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Research, 221, 105778 (21 pp.). https://doi.org/10.1016/j.antiviral.2023.105778 |
| Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
Amrhein, J. A., Berger, L. M., Balourdas, D. I., Joerger, A. C., Menge, A., Krämer, A., … Hanke, T. (2024). Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3. Journal of Medicinal Chemistry, 67(1), 674-690. https://doi.org/10.1021/acs.jmedchem.3c01980 |
| Development of a series of pyrrolopyridone MAT2A inhibitors
Atkinson, S. J., Bagal, S. K., Argyrou, A., Askin, S., Cheung, T., Chiarparin, E., … Williamson, B. (2024). Development of a series of pyrrolopyridone MAT2A inhibitors. Journal of Medicinal Chemistry, 67(6), 4541-4559. https://doi.org/10.1021/acs.jmedchem.3c01860 |
| Heterometallic transition metal oxides containing lewis acids as molecular catalysts for the reduction of carbon dioxide to carbon monoxide with bimodal activity
Azaiza-Dabbah, D., Wang, F., Haddad, E., Solé-Daura, A., Carmieli, R., Poblet, J. M., … Neumann, R. (2024). Heterometallic transition metal oxides containing lewis acids as molecular catalysts for the reduction of carbon dioxide to carbon monoxide with bimodal activity. Journal of the American Chemical Society, 146(40), 27871-27885. https://doi.org/10.1021/jacs.4c10412 |
| Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
Balourdas, D. I., Markl, A. M., Krämer, A., Settanni, G., & Joerger, A. C. (2024). Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators. Cell Death & Disease, 15(6), 408. https://doi.org/10.1038/s41419-024-06739-x |
| Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
Baltgalvis, K. A., Lamb, K. N., Symons, K. T., Wu, C. C., Hoffman, M. A., Snead, A. N., … Kinsella, T. M. (2024). Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature, 629(8011), 435-442. https://doi.org/10.1038/s41586-024-07318-y |
| Discovery and structural characterization of a thermostable bacterial monoamine oxidase
Basile, L., Santema, L. L., Binda, C., & Fraaije, M. W. (2024). Discovery and structural characterization of a thermostable bacterial monoamine oxidase. FEBS Journal, 291, 849-864. https://doi.org/10.1111/febs.16973 |
| Viral peptide conjugates for metal-warhead delivery to chromatin
Batchelor, L. K., De Falco, L., Dyson, P. J., & Davey, C. A. (2024). Viral peptide conjugates for metal-warhead delivery to chromatin. RSC Advances, 14(13), 8718-8725. https://doi.org/10.1039/d4ra01617c |
| Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization
Bauer, N., Balourdas, D. I., Schneider, J. R., Zhang, X., Berger, L. M., Berger, B. T., … Joerger, A. C. (2024). Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization. ACS Chemical Biology, 19(2), 266-279. https://doi.org/10.1021/acschembio.3c00427 |
| Metadynamics simulations reveal alloying-dealloying processes for bimetallic PdGa nanoparticles under CO<sub>2</sub> hydrogenation
Baumgärtner, J. F., Müller, A., Docherty, S. R., Comas-Vives, A., Payard, P. A., & Copéret, C. (2024). Metadynamics simulations reveal alloying-dealloying processes for bimetallic PdGa nanoparticles under CO2 hydrogenation. Chemical Science, 15, 4871-4880. https://doi.org/10.1039/d4sc00484a |
| Probing protein-ligand methyl−π interaction geometries through chemical shift measurements of selectively labeled methyl groups
Beier, A., Platzer, G., Höfurthner, T., Ptaszek, A. L., Lichtenecker, R. J., Geist, L., … Konrat, R. (2024). Probing protein-ligand methyl−π interaction geometries through chemical shift measurements of selectively labeled methyl groups. Journal of Medicinal Chemistry, 67(15), 13187-13196. https://doi.org/10.1021/acs.jmedchem.4c01128 |
| Primordial magnetotaxis in putative giant paleoproterozoic magnetofossils
Bellon, U. D., Williams, W., Trindade, R. I. F., Maldanis, L., & Galante, D. (2024). Primordial magnetotaxis in putative giant paleoproterozoic magnetofossils. Proceedings of the National Academy of Sciences of the United States of America PNAS, 121(23), e2319148121 (10 pp.). https://doi.org/10.1073/pnas.2319148121 |
| PROTACs targeting BRM (SMARCA2) afford selective <em>In vivo</em> degradation over BRG1 (SMARCA4) and are active in BRG1 mutant xenograft tumor models
Berlin, M., Cantley, J., Bookbinder, M., Bortolon, E., Broccatelli, F., Cadelina, G., … Dragovich, P. S. (2024). PROTACs targeting BRM (SMARCA2) afford selective In vivo degradation over BRG1 (SMARCA4) and are active in BRG1 mutant xenograft tumor models. Journal of Medicinal Chemistry, 67, 1262-1313. https://doi.org/10.1021/acs.jmedchem.3c01781 |
| Impact of nickel on iridium–ruthenium structure and activity for the oxygen evolution reaction under acidic conditions
Bertheussen, E., Pitscheider, S., Cooper, S. R., Pittkowski, R., Svane, K. L., Bornet, A., … Pedersen, C. M. (2024). Impact of nickel on iridium–ruthenium structure and activity for the oxygen evolution reaction under acidic conditions. ACS Materials Au, 4(5), 512-522. https://doi.org/10.1021/acsmaterialsau.4c00025 |
| Impact of Cu<sup>+</sup> and Cu<sup>2+</sup> species on the oxide-metal transition processes of Cu<sub>x</sub>O foams during the CO<sub>2</sub>RR probed by operando Quick-XAS
Blaseio, S., Dosche, C., Rahaman, M., Kiran, K., Dworzak, A., Mahrt, B., … Oezaslan, M. (2024). Impact of Cu+ and Cu2+ species on the oxide-metal transition processes of CuxO foams during the CO2RR probed by operando Quick-XAS. Journal of Materials Chemistry A, 12(41), 28177-28192. https://doi.org/10.1039/d4ta02217c |
| High-resolution vision in pelagic polychaetes
Bok, M. J., Macali, A., & Garm, A. (2024). High-resolution vision in pelagic polychaetes. Current Biology, 34(7), R269-R270. https://doi.org/10.1016/j.cub.2024.02.055 |
| A tiny pocket packs a punch: leveraging pyridones for the discovery of CNS-penetrant aza-indazole IRAK4 inhibitors
Bolduc, P. N., Pfaffenbach, M., Evans, R., Xin, Z., Henry, K. L., Gao, F., … Peterson, E. A. (2024). A tiny pocket packs a punch: leveraging pyridones for the discovery of CNS-penetrant aza-indazole IRAK4 inhibitors. ACS Medicinal Chemistry Letters, 15(5), 714-721. https://doi.org/10.1021/acsmedchemlett.4c00102 |
| Discovery of IRAK4 inhibitors BAY1834845 (zabedosertib) and BAY1830839
Bothe, U., Günther, J., Nubbemeyer, R., Siebeneicher, H., Ring, S., Bömer, U., … Schmidt, N. (2024). Discovery of IRAK4 inhibitors BAY1834845 (zabedosertib) and BAY1830839. Journal of Medicinal Chemistry, 67, 1225-1242. https://doi.org/10.1021/acs.jmedchem.3c01714 |
| Evolution-inspired engineering of nonribosomal peptide synthetases
Bozhüyük, K. A. J., Präve, L., Kegler, C., Schenk, L., Kaiser, S., Schelhas, C., … Bode, H. B. (2024). Evolution-inspired engineering of nonribosomal peptide synthetases. Science, 383(6689), eadg4320 (11 pp.). https://doi.org/10.1126/science.adg4320 |
| A novel <em>O-</em> and <em>S</em>-methyltransferase from <em>Pleurotus </em>sapidus is involved in flavor formation
Brescia, F. F., Korf, L., Essen, L. O., Zorn, H., & Ruehl, M. (2024). A novel O- and S-methyltransferase from Pleurotus sapidus is involved in flavor formation. Journal of Agricultural and Food Chemistry, 72(12), 6471-6480. https://doi.org/10.1021/acs.jafc.3c08849 |