| A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol
Reynders, M., Garścia, M., Müller-Deku, A., Wranik, M., Krauskopf, K., de la Osa de la Rosa, L., … Thorn-Seshold, O. (2024). A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol. Chemical Science, 15(31), 12301-12309. https://doi.org/10.1039/d4sc03072a |
| Chemical modulation of microtubule structure through the laulimalide/peloruside site
Estévez-Gallego, J., Álvarez-Bernad, B., Pera, B., Wullschleger, C., Raes, O., Menche, D., … Oliva, M. Á. (2023). Chemical modulation of microtubule structure through the laulimalide/peloruside site. Structure, 31(1), 88-99.e5. https://doi.org/10.1016/j.str.2022.11.006 |
| Multivalency ensures persistence of a +TIP body at specialized microtubule ends
Meier, S. M., Farcas, A. M., Kumar, A., Ijavi, M., Bill, R. T., Stelling, J., … Barral, Y. (2023). Multivalency ensures persistence of a +TIP body at specialized microtubule ends. Nature Cell Biology, 25, 56-67. https://doi.org/10.1038/s41556-022-01035-2 |
| Rational design of a novel tubulin inhibitor with a unique mechanism of action
Mühlethaler, T., Milanos, L., Ortega, J. A., Blum, T. B., Gioia, D., Roy, B., … Steinmetz, M. O. (2022). Rational design of a novel tubulin inhibitor with a unique mechanism of action. Angewandte Chemie International Edition, 61(25), e202204052 (11 pp.). https://doi.org/10.1002/anie.202204052 |
| Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
de la Roche, N. M., Mühlethaler, T., Di Martino, R. M. C., Ortega, J. A., Gioia, D., Roy, B., … Cavalli, A. (2022). Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents. European Journal of Medicinal Chemistry, 241, 114614 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114614 |
| A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton
Gao, L., Meiring, J. C. M., Kraus, Y., Wranik, M., Weinert, T., Pritzl, S. D., … Thorn-Seshold, O. (2021). A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton. Cell Chemical Biology, 28(2), 228-241. https://doi.org/10.1016/j.chembiol.2020.11.007 |
| Structure and regulation of the microtubule plus-end tracking protein Kar9
Kumar, A., Meier, S. M., Farcas, A. M., Manatschal, C., Barral, Y., & Steinmetz, M. O. (2021). Structure and regulation of the microtubule plus-end tracking protein Kar9. Structure, 29(11), 1266-1278.e4. https://doi.org/10.1016/j.str.2021.06.012 |
| Comprehensive analysis of binding sites in tubulin
Mühlethaler, T., Gioia, D., Prota, A. E., Sharpe, M. E., Cavalli, A., & Steinmetz, M. O. (2021). Comprehensive analysis of binding sites in tubulin. Angewandte Chemie International Edition, 60(24), 13331-13342. https://doi.org/10.1002/anie.202100273 |
| The mechanism of kinesin inhibition by kinesin binding protein
Atherton, J., Hummel, J. J. A., Olieric, N., Locke, J., Peña, A., Rosenfeld, S. S., … Moores, C. A. (2020). The mechanism of kinesin inhibition by kinesin binding protein. eLife, 9, e61481 (30 pp.). https://doi.org/10.7554/eLife.61481 |
| Structural model for differential cap maturation at growing microtubule ends
Estévez-Gallego, J., Josa-Prado, F., Ku, S., Buey, R. M., Balaguer, F. A., Prota, A. E., … Oliva, M. A. (2020). Structural model for differential cap maturation at growing microtubule ends. eLife, 9, e50155 (26 pp.). https://doi.org/10.7554/eLife.50155 |
| Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence
Guo, B., Rodriguez-Gabin, A., Prota, A. E., Mühlethaler, T., Zhang, N., Ye, K., … McDaid, H. M. (2020). Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence. Molecular Pharmacology, 98(2), 156-167. https://doi.org/10.1124/mol.119.117457 |
| Pharmaceutical-grade rigosertib is a microtubule-destabilizing agent
Jost, M., Chen, Y., Gilbert, L. A., Horlbeck, M. A., Krenning, L., Menchon, G., … Weissman, J. S. (2020). Pharmaceutical-grade rigosertib is a microtubule-destabilizing agent. Molecular Cell, 79(1), 191-198.e3. https://doi.org/10.1016/j.molcel.2020.06.008 |
| Advances in long-wavelength native phasing at X-ray free-electron lasers
Nass, K., Cheng, R., Vera, L., Mozzanica, A., Redford, S., Ozerov, D., … Milne, C. J. (2020). Advances in long-wavelength native phasing at X-ray free-electron lasers. IUCrJ, 7, 965-975. https://doi.org/10.1107/S2052252520011379 |
| Structural basis of noscapine activation for tubulin binding
Oliva, M. A., Prota, A. E., Rodríguez-Salarichs, J., Bennani, Y. L., Jiménez-Barbero, J., Bargsten, K., … Díaz, J. F. (2020). Structural basis of noscapine activation for tubulin binding. Journal of Medicinal Chemistry, 63(15), 8495-8501. https://doi.org/10.1021/acs.jmedchem.0c00855 |
| Mechanisms of motor-independent membrane remodeling driven by dynamic microtubules
Rodríguez-García, R., Volkov, V. A., Chen, C. Y., Katrukha, E. A., Olieric, N., Aher, A., … Akhmanova, A. (2020). Mechanisms of motor-independent membrane remodeling driven by dynamic microtubules. Current Biology, 30(6), 972-987. https://doi.org/10.1016/j.cub.2020.01.036 |
| WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity
Steib, E., Laporte, M. H., Gambarotto, D., Olieric, N., Zheng, C., Borgers, S., … Hamel, V. (2020). WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity. eLife, 9, e57205 (28 pp.). https://doi.org/10.7554/ELIFE.57205 |
| Microtubule minus-end regulation at a glance
Akhmanova, A., & Steinmetz, M. O. (2019). Microtubule minus-end regulation at a glance. Journal of Cell Science, 132(11), jcs227850 (7 pp.). https://doi.org/10.1242/jcs.227850 |
| Structural determinants of microtubule minus end preference in CAMSAP CKK domains
Atherton, J., Luo, Y., Xiang, S., Yang, C., Rai, A., Jiang, K., … Moores, C. A. (2019). Structural determinants of microtubule minus end preference in CAMSAP CKK domains. Nature Communications, 10(1), 5236 (16 pp.). https://doi.org/10.1038/s41467-019-13247-6 |
| Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents
Brindisi, M., Ulivieri, C., Alfano, G., Gemma, S., de Asís Balaguer, F., Khan, T., … Brogi, S. (2019). Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents. European Journal of Medicinal Chemistry, 162, 290-320. https://doi.org/10.1016/j.ejmech.2018.11.004 |
| Remote control of microtubule plus-end dynamics and function from the minus-end
Chen, X., Widmer, L. A., Stangier, M. M., Steinmetz, M. O., Stelling, J., & Barral, Y. (2019). Remote control of microtubule plus-end dynamics and function from the minus-end. eLife, 8, e48627 (32 pp.). https://doi.org/10.7554/eLife.48627 |
