| Modular synthesis of functional libraries by accelerated SuFEx click chemistry
Homer, J. A., Koelln, R. A., Barrow, A. S., Gialelis, T. L., Boiarska, Z., Steinohrt, N. S., … Moses, J. E. (2024). Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chemical Science. https://doi.org/10.1039/d3sc05729a |
| Maytansinol functionalization: towards useful probes for studying microtubule dynamics
Boiarska, Z., Pérez-Peña, H., Abel, A. C., Marzullo, P., Álvarez-Bernad, B., Bonato, F., … Passarella, D. (2023). Maytansinol functionalization: towards useful probes for studying microtubule dynamics. Chemistry: A European Journal, 29(5), e202203431 (12 pp.). https://doi.org/10.1002/chem.202203431 |
| Chemical modulation of microtubule structure through the laulimalide/peloruside site
Estévez-Gallego, J., Álvarez-Bernad, B., Pera, B., Wullschleger, C., Raes, O., Menche, D., … Oliva, M. Á. (2023). Chemical modulation of microtubule structure through the laulimalide/peloruside site. Structure, 31(1), 88-99.e5. https://doi.org/10.1016/j.str.2022.11.006 |
| Structural insight into the stabilization of microtubules by taxanes
Prota, A. E., Lucena-Agell, D., Ma, Y., Estevez-Gallego, J., Li, S., Bargsten, K., … Díaz, J. F. (2023). Structural insight into the stabilization of microtubules by taxanes. eLife, 12, e84791 (35 pp.). https://doi.org/10.7554/elife.84791 |
| Computational approaches to the rational design of tubulin-targeting agents
Pérez-Peña, H., Abel, A. C., Shevelev, M., Prota, A. E., Pieraccini, S., & Horvath, D. (2023). Computational approaches to the rational design of tubulin-targeting agents. Biomolecules, 13(2), 285 (35 pp.). https://doi.org/10.3390/biom13020285 |
| Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: further chemical modifications and potential therapeutic effects against lymphomas
Barreca, M., Spanò, V., Rocca, R., Bivacqua, R., Abel, A. C., Maruca, A., … Barraja, P. (2022). Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: further chemical modifications and potential therapeutic effects against lymphomas. European Journal of Medicinal Chemistry, 243, 114744 (25 pp.). https://doi.org/10.1016/j.ejmech.2022.114744 |
| Maytansinol derivatives: side reactions as a chance for new tubulin binders
Marzullo, P., Boiarska, Z., Pérez-Peña, H., Abel, A. C., Álvarez-Bernad, B., Lucena-Agell, D., … Passarella, D. (2022). Maytansinol derivatives: side reactions as a chance for new tubulin binders. Chemistry: A European Journal, 28(2), e202103520 (10 pp.). https://doi.org/10.1002/chem.202103520 |
| Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes
Mühlethaler, T., Olieric, N., Ehrhard, V. A., Wranik, M., Standfuss, J., Sharma, A., … Steinmetz, M. O. (2022). Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes. In H. Inaba (Ed.), Methods in molecular biology: Vol. 2430. Microtubules. Methods and protocols (pp. 349-374). https://doi.org/10.1007/978-1-0716-1983-4_23 |
| Rational design of a novel tubulin inhibitor with a unique mechanism of action
Mühlethaler, T., Milanos, L., Ortega, J. A., Blum, T. B., Gioia, D., Roy, B., … Steinmetz, M. O. (2022). Rational design of a novel tubulin inhibitor with a unique mechanism of action. Angewandte Chemie International Edition, 61(25), e202204052 (11 pp.). https://doi.org/10.1002/anie.202204052 |
| Cu<sup>2+</sup> ions modulate the interaction between α-synuclein and lipid membranes
Wang, H., Mörman, C., Sternke-Hoffmann, R., Huang, C. Y., Prota, A., Ma, P., & Luo, J. (2022). Cu2+ ions modulate the interaction between α-synuclein and lipid membranes. Journal of Inorganic Biochemistry, 236, 111945 (10 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111945 |
| Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
de la Roche, N. M., Mühlethaler, T., Di Martino, R. M. C., Ortega, J. A., Gioia, D., Roy, B., … Cavalli, A. (2022). Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents. European Journal of Medicinal Chemistry, 241, 114614 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114614 |
| Preclinical and early clinical development of PTC596, a novel small-molecule tubulin-binding agent
Jernigan, F., Branstrom, A., Baird, J. D., Cao, L., Dali, M., Furia, B., … Weetall, M. (2021). Preclinical and early clinical development of PTC596, a novel small-molecule tubulin-binding agent. Molecular Cancer Therapeutics, 20(10), 1846-1857. https://doi.org/10.1158/1535-7163.MCT-20-0774 |
| Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site
Matthew, S., Chen, Q. Y., Ratnayake, R., Fermaintt, C. S., Lucena-Agell, D., Bonato, F., … Luesch, H. (2021). Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site. Proceedings of the National Academy of Sciences of the United States of America PNAS, 118(9), e2021847118 (11 pp.). https://doi.org/10.1073/pnas.2021847118 |
| Comprehensive analysis of binding sites in tubulin
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| Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in <em>Streptomyces</em>
Xiao, X., Willemse, J., Voskamp, P., Li, X., Prota, A. E., Lamers, M., … van Wezel, G. P. (2021). Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces. Open Biology, 11(2), 200409 (14 pp.). https://doi.org/10.1098/rsob.200409 |
| 1,3-benzodioxole-modified noscapine analogues: synthesis, antiproliferative activity, and tubulin-bound structure
Yong, C., Devine, S. M., Abel, A. C., Tomlins, S. D., Muthiah, D., Gao, X., … Scammells, P. J. (2021). 1,3-benzodioxole-modified noscapine analogues: synthesis, antiproliferative activity, and tubulin-bound structure. ChemMedChem, 16(18), 2882-2894. https://doi.org/10.1002/cmdc.202100363 |
| Structural model for differential cap maturation at growing microtubule ends
Estévez-Gallego, J., Josa-Prado, F., Ku, S., Buey, R. M., Balaguer, F. A., Prota, A. E., … Oliva, M. A. (2020). Structural model for differential cap maturation at growing microtubule ends. eLife, 9, e50155 (26 pp.). https://doi.org/10.7554/eLife.50155 |
| Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence
Guo, B., Rodriguez-Gabin, A., Prota, A. E., Mühlethaler, T., Zhang, N., Ye, K., … McDaid, H. M. (2020). Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence. Molecular Pharmacology, 98(2), 156-167. https://doi.org/10.1124/mol.119.117457 |
| Pharmaceutical-grade rigosertib is a microtubule-destabilizing agent
Jost, M., Chen, Y., Gilbert, L. A., Horlbeck, M. A., Krenning, L., Menchon, G., … Weissman, J. S. (2020). Pharmaceutical-grade rigosertib is a microtubule-destabilizing agent. Molecular Cell, 79(1), 191-198.e3. https://doi.org/10.1016/j.molcel.2020.06.008 |
| Structural basis of noscapine activation for tubulin binding
Oliva, M. A., Prota, A. E., Rodríguez-Salarichs, J., Bennani, Y. L., Jiménez-Barbero, J., Bargsten, K., … Díaz, J. F. (2020). Structural basis of noscapine activation for tubulin binding. Journal of Medicinal Chemistry, 63(15), 8495-8501. https://doi.org/10.1021/acs.jmedchem.0c00855 |