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A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton
Gao, L., Meiring, J. C. M., Kraus, Y., Wranik, M., Weinert, T., Pritzl, S. D., … Thorn-Seshold, O. (2021). A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton. Cell Chemical Biology, 28(2), 228-241. https://doi.org/10.1016/j.chembiol.2020.11.007
Surface tensiometry of phase separated protein and polymer droplets by the sessile drop method
Ijavi, M., Style, R. W., Emmanouilidis, L., Kumar, A., Meier, S. M., Torzynski, A. L., … Dufresne, E. R. (2021). Surface tensiometry of phase separated protein and polymer droplets by the sessile drop method. Soft Matter, 17(6), 1655-1662. https://doi.org/10.1039/d0sm01319f
Comprehensive analysis of binding sites in tubulin
Mühlethaler, T., Gioia, D., Prota, A. E., Sharpe, M. E., Cavalli, A., & Steinmetz, M. O. (2021). Comprehensive analysis of binding sites in tubulin. Angewandte Chemie International Edition, 60(24), 13331-13342. https://doi.org/10.1002/anie.202100273
Centriole length control
Sharma, A., Olieric, N., & Steinmetz, M. O. (2021). Centriole length control. Current Opinion in Structural Biology, 66, 89-95. https://doi.org/10.1016/j.sbi.2020.10.011
The mechanism of kinesin inhibition by kinesin binding protein
Atherton, J., Hummel, J. J. A., Olieric, N., Locke, J., Peña, A., Rosenfeld, S. S., … Moores, C. A. (2020). The mechanism of kinesin inhibition by kinesin binding protein. eLife, 9, e61481 (30 pp.). https://doi.org/10.7554/eLife.61481
Structural model for differential cap maturation at growing microtubule ends
Estévez-Gallego, J., Josa-Prado, F., Ku, S., Buey, R. M., Balaguer, F. A., Prota, A. E., … Oliva, M. A. (2020). Structural model for differential cap maturation at growing microtubule ends. eLife, 9, e50155 (26 pp.). https://doi.org/10.7554/eLife.50155
Homodimerization of coronin A through the C-terminal coiled-coil domain is essential for multicellular differentiation of <em>Dictyostelium discoideum</em>
Fiedler, T., Fabrice, T. N., Studer, V., Vinet, A., Faltova, L., Kammerer, R. A., … Pieters, J. (2020). Homodimerization of coronin A through the C-terminal coiled-coil domain is essential for multicellular differentiation of Dictyostelium discoideum. FEBS Letters, 594(13), 2116-2127. https://doi.org/10.1002/1873-3468.13787
Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence
Guo, B., Rodriguez-Gabin, A., Prota, A. E., Mühlethaler, T., Zhang, N., Ye, K., … McDaid, H. M. (2020). Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence. Molecular Pharmacology, 98(2), 156-167. https://doi.org/10.1124/mol.119.117457
Pharmaceutical-grade rigosertib is a microtubule-destabilizing agent
Jost, M., Chen, Y., Gilbert, L. A., Horlbeck, M. A., Krenning, L., Menchon, G., … Weissman, J. S. (2020). Pharmaceutical-grade rigosertib is a microtubule-destabilizing agent. Molecular Cell, 79(1), 191-198.e3. https://doi.org/10.1016/j.molcel.2020.06.008
Advances in long-wavelength native phasing at X-ray free-electron lasers
Nass, K., Cheng, R., Vera, L., Mozzanica, A., Redford, S., Ozerov, D., … Milne, C. J. (2020). Advances in long-wavelength native phasing at X-ray free-electron lasers. IUCrJ, 7, 965-975. https://doi.org/10.1107/S2052252520011379
Structural basis of noscapine activation for tubulin binding
Oliva, M. A., Prota, A. E., Rodríguez-Salarichs, J., Bennani, Y. L., Jiménez-Barbero, J., Bargsten, K., … Díaz, J. F. (2020). Structural basis of noscapine activation for tubulin binding. Journal of Medicinal Chemistry, 63(15), 8495-8501. https://doi.org/10.1021/acs.jmedchem.0c00855
Mechanisms of motor-independent membrane remodeling driven by dynamic microtubules
Rodríguez-García, R., Volkov, V. A., Chen, C. Y., Katrukha, E. A., Olieric, N., Aher, A., … Akhmanova, A. (2020). Mechanisms of motor-independent membrane remodeling driven by dynamic microtubules. Current Biology, 30(6), 972-987. https://doi.org/10.1016/j.cub.2020.01.036
WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity
Steib, E., Laporte, M. H., Gambarotto, D., Olieric, N., Zheng, C., Borgers, S., … Hamel, V. (2020). WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity. eLife, 9, e57205 (28 pp.). https://doi.org/10.7554/ELIFE.57205
Microtubule minus-end regulation at a glance
Akhmanova, A., & Steinmetz, M. O. (2019). Microtubule minus-end regulation at a glance. Journal of Cell Science, 132(11), jcs227850 (7 pp.). https://doi.org/10.1242/jcs.227850
Structural determinants of microtubule minus end preference in CAMSAP CKK domains
Atherton, J., Luo, Y., Xiang, S., Yang, C., Rai, A., Jiang, K., … Moores, C. A. (2019). Structural determinants of microtubule minus end preference in CAMSAP CKK domains. Nature Communications, 10(1), 5236 (16 pp.). https://doi.org/10.1038/s41467-019-13247-6
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents
Brindisi, M., Ulivieri, C., Alfano, G., Gemma, S., de Asís Balaguer, F., Khan, T., … Brogi, S. (2019). Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents. European Journal of Medicinal Chemistry, 162, 290-320. https://doi.org/10.1016/j.ejmech.2018.11.004
Remote control of microtubule plus-end dynamics and function from the minus-end
Chen, X., Widmer, L. A., Stangier, M. M., Steinmetz, M. O., Stelling, J., & Barral, Y. (2019). Remote control of microtubule plus-end dynamics and function from the minus-end. eLife, 8, e48627 (32 pp.). https://doi.org/10.7554/eLife.48627
Structural basis of colchicine-site targeting acylhydrazones active against multidrug-resistant acute lymphoblastic leukemia
Cury, N. M., Mühlethaler, T., Laranjeira, A. B. A., Canevarolo, R. R., Zenatti, P. P., Lucena-Agell, D., … Yunes, J. A. (2019). Structural basis of colchicine-site targeting acylhydrazones active against multidrug-resistant acute lymphoblastic leukemia. iScience, 21, 95-109. https://doi.org/10.1016/j.isci.2019.10.003
Tetrahydroisoquinoline sulfamates as potent microtubule disruptors: synthesis, antiproliferative and antitubulin activity of dichlorobenzyl-based derivatives, and a Tubulin cocrystal structure.
Dohle, W., Prota, A. E., Menchon, G., Hamel, E., Steinmetz, M. O., & Potter, B. V. L. (2019). Tetrahydroisoquinoline sulfamates as potent microtubule disruptors: synthesis, antiproliferative and antitubulin activity of dichlorobenzyl-based derivatives, and a Tubulin cocrystal structure. ACS Omega, 4, 755-764. https://doi.org/10.1021/acsomega.8b02879
Conformational properties of the chemotherapeutic drug analogue Epothilone A: how to model a flexible protein ligand using scarcely available experimental data
Dolenc, J., van Gunsteren, W. F., Prota, A. E., Steinmetz, M. O., & Missimer, J. H. (2019). Conformational properties of the chemotherapeutic drug analogue Epothilone A: how to model a flexible protein ligand using scarcely available experimental data. Journal of Chemical Information and Modeling, 59(5), 2218-2230. https://doi.org/10.1021/acs.jcim.9b00171
 

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