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Modular synthesis of functional libraries by accelerated SuFEx click chemistry
Homer, J. A., Koelln, R. A., Barrow, A. S., Gialelis, T. L., Boiarska, Z., Steinohrt, N. S., … Moses, J. E. (2024). Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chemical Science. https://doi.org/10.1039/d3sc05729a
Microtubule specialization by +TIP networks: from mechanisms to functional implications
Meier, S. M., Steinmetz, M. O., & Barral, Y. (2024). Microtubule specialization by +TIP networks: from mechanisms to functional implications. Trends in Biochemical Sciences. https://doi.org/10.1016/j.tibs.2024.01.005
The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips
Chen, X., Portran, D., Widmer, L. A., Stangier, M. M., Czub, M. P., Liakopoulos, D., … Barral, Y. (2023). The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips. Journal of Cell Biology, 222(7), e202110126 (18 pp.). https://doi.org/10.1083/jcb.202110126
Chemical modulation of microtubule structure through the laulimalide/peloruside site
Estévez-Gallego, J., Álvarez-Bernad, B., Pera, B., Wullschleger, C., Raes, O., Menche, D., … Oliva, M. Á. (2023). Chemical modulation of microtubule structure through the laulimalide/peloruside site. Structure, 31(1), 88-99.e5. https://doi.org/10.1016/j.str.2022.11.006
Multivalency ensures persistence of a +TIP body at specialized microtubule ends
Meier, S. M., Farcas, A. M., Kumar, A., Ijavi, M., Bill, R. T., Stelling, J., … Barral, Y. (2023). Multivalency ensures persistence of a +TIP body at specialized microtubule ends. Nature Cell Biology, 25, 56-67. https://doi.org/10.1038/s41556-022-01035-2
Structural insight into the stabilization of microtubules by taxanes
Prota, A. E., Lucena-Agell, D., Ma, Y., Estevez-Gallego, J., Li, S., Bargsten, K., … Díaz, J. F. (2023). Structural insight into the stabilization of microtubules by taxanes. eLife, 12, e84791 (35 pp.). https://doi.org/10.7554/elife.84791
VASH1–SVBP and VASH2–SVBP generate different detyrosination profiles on microtubules
Ramirez-Rios, S., Choi, S. R., Sanyal, C., Blum, T. B., Bosc, C., Krichen, F., … Moutin, M. J. (2023). VASH1–SVBP and VASH2–SVBP generate different detyrosination profiles on microtubules. Journal of Cell Biology, 222(2), e202205096 (30 pp.). https://doi.org/10.1083/jcb.202205096
A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers
Wranik, M., Kepa, M. W., Beale, E. V., James, D., Bertrand, Q., Weinert, T., … Standfuss, J. (2023). A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers. Nature Communications, 14(1), 7956 (12 pp.). https://doi.org/10.1038/s41467-023-43523-5
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
Wranik, M., Weinert, T., Slavov, C., Masini, T., Furrer, A., Gaillard, N., … Standfuss, J. (2023). Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography. Nature Communications, 14(1), 903 (12 pp.). https://doi.org/10.1038/s41467-023-36481-5
Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: further chemical modifications and potential therapeutic effects against lymphomas
Barreca, M., Spanò, V., Rocca, R., Bivacqua, R., Abel, A. C., Maruca, A., … Barraja, P. (2022). Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: further chemical modifications and potential therapeutic effects against lymphomas. European Journal of Medicinal Chemistry, 243, 114744 (25 pp.). https://doi.org/10.1016/j.ejmech.2022.114744
<em>In vivo</em> photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M
Gao, L., Meiring, J. C. M., Varady, A., Ruider, I. E., Heise, C., Wranik, M., … Thorn-Seshold, O. (2022). In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M. Journal of the American Chemical Society, 144(12), 5614-5628. https://doi.org/10.1021/jacs.2c01020
Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in <em>Xenopus </em>egg cytoplasmic extracts
Guyomar, C., Bousquet, C., Ku, S., Heumann, J. M., Guilloux, G., Gaillard, N., … Chrétien, D. (2022). Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in Xenopus egg cytoplasmic extracts. eLife, 11, e83021 (26 pp.). https://doi.org/10.7554/eLife.83021
Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes
Mühlethaler, T., Olieric, N., Ehrhard, V. A., Wranik, M., Standfuss, J., Sharma, A., … Steinmetz, M. O. (2022). Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes. In H. Inaba (Ed.), Methods in molecular biology: Vol. 2430. Microtubules. Methods and protocols (pp. 349-374). https://doi.org/10.1007/978-1-0716-1983-4_23
Rational design of a novel tubulin inhibitor with a unique mechanism of action
Mühlethaler, T., Milanos, L., Ortega, J. A., Blum, T. B., Gioia, D., Roy, B., … Steinmetz, M. O. (2022). Rational design of a novel tubulin inhibitor with a unique mechanism of action. Angewandte Chemie International Edition, 61(25), e202204052 (11 pp.). https://doi.org/10.1002/anie.202204052
Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
de la Roche, N. M., Mühlethaler, T., Di Martino, R. M. C., Ortega, J. A., Gioia, D., Roy, B., … Cavalli, A. (2022). Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents. European Journal of Medicinal Chemistry, 241, 114614 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114614
Inhibiting parasite proliferation using a rationally designed anti-tubulin agent
Gaillard, N., Sharma, A., Abbaali, I., Liu, T., Shilliday, F., Cook, A. D., … Steinmetz, M. O. (2021). Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. EMBO Molecular Medicine, 13(11), e13818 (12 pp.). https://doi.org/10.15252/emmm.202013818
A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton
Gao, L., Meiring, J. C. M., Kraus, Y., Wranik, M., Weinert, T., Pritzl, S. D., … Thorn-Seshold, O. (2021). A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton. Cell Chemical Biology, 28(2), 228-241. https://doi.org/10.1016/j.chembiol.2020.11.007
Surface tensiometry of phase separated protein and polymer droplets by the sessile drop method
Ijavi, M., Style, R. W., Emmanouilidis, L., Kumar, A., Meier, S. M., Torzynski, A. L., … Dufresne, E. R. (2021). Surface tensiometry of phase separated protein and polymer droplets by the sessile drop method. Soft Matter, 17(6), 1655-1662. https://doi.org/10.1039/d0sm01319f
Preclinical and early clinical development of PTC596, a novel small-molecule tubulin-binding agent
Jernigan, F., Branstrom, A., Baird, J. D., Cao, L., Dali, M., Furia, B., … Weetall, M. (2021). Preclinical and early clinical development of PTC596, a novel small-molecule tubulin-binding agent. Molecular Cancer Therapeutics, 20(10), 1846-1857. https://doi.org/10.1158/1535-7163.MCT-20-0774
Structure and regulation of the microtubule plus-end tracking protein Kar9
Kumar, A., Meier, S. M., Farcas, A. M., Manatschal, C., Barral, Y., & Steinmetz, M. O. (2021). Structure and regulation of the microtubule plus-end tracking protein Kar9. Structure, 29(11), 1266-1278.e4. https://doi.org/10.1016/j.str.2021.06.012
 

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