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  • (-) PSI Authors = Steinmetz, Michel O.
  • (-) Keywords = X-ray crystallography
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Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: further chemical modifications and potential therapeutic effects against lymphomas
Barreca, M., Spanò, V., Rocca, R., Bivacqua, R., Abel, A. C., Maruca, A., … Barraja, P. (2022). Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: further chemical modifications and potential therapeutic effects against lymphomas. European Journal of Medicinal Chemistry, 243, 114744 (25 pp.). https://doi.org/10.1016/j.ejmech.2022.114744
Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes
Mühlethaler, T., Olieric, N., Ehrhard, V. A., Wranik, M., Standfuss, J., Sharma, A., … Steinmetz, M. O. (2022). Crystallization systems for the high-resolution structural analysis of tubulin-ligand complexes. In H. Inaba (Ed.), Methods in molecular biology: Vol. 2430. Microtubules. Methods and protocols (pp. 349-374). https://doi.org/10.1007/978-1-0716-1983-4_23
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents
Brindisi, M., Ulivieri, C., Alfano, G., Gemma, S., de Asís Balaguer, F., Khan, T., … Brogi, S. (2019). Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents. European Journal of Medicinal Chemistry, 162, 290-320. https://doi.org/10.1016/j.ejmech.2018.11.004
Cep120 promotes microtubule formation through a unique tubulin binding C2 domain
Sharma, A., Gerard, S. F., Olieric, N., & Steinmetz, M. O. (2018). Cep120 promotes microtubule formation through a unique tubulin binding C2 domain. Journal of Structural Biology, 203(1), 62-70. https://doi.org/10.1016/j.jsb.2018.01.009
Structural basis of microtubule stabilization by discodermolide
Prota, A. E., Bargsten, K., Redondo-Horcajo, M., Smith, A. B., Yang, C. P. H., McDaid, H. M., … Steinmetz, M. O. (2017). Structural basis of microtubule stabilization by discodermolide. ChemBioChem, 18(10), 905-909. https://doi.org/10.1002/cbic.201600696
Pironetin binds covalently to αCys316 and perturbs a major loop and helix of α-tubulin to inhibit microtubule formation
Prota, A. E., Setter, J., Waight, A. B., Bargsten, K., Murga, J., Diaz, J. F., & Steinmetz, M. O. (2016). Pironetin binds covalently to αCys316 and perturbs a major loop and helix of α-tubulin to inhibit microtubule formation. Journal of Molecular Biology, 428(15), 2981-2988. https://doi.org/10.1016/j.jmb.2016.06.023
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
Prota, A. E., Bargsten, K., Diaz, J. F., Marsh, M., Cuevas, C., Liniger, M., … Steinmetz, M. O. (2014). A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proceedings of the National Academy of Sciences of the United States of America PNAS, 111(38), 13817-13821. https://doi.org/10.1073/pnas.1408124111
Structural basis of microtubule stabilization by laulimalide and peloruside A
Prota, A. E., Bargsten, K., Northcote, P. T., Marsh, M., Altmann, K. H., Miller, J. H., … Steinmetz, M. O. (2014). Structural basis of microtubule stabilization by laulimalide and peloruside A. Angewandte Chemie International Edition, 53(6), 1621-1625. https://doi.org/10.1002/anie.201307749
The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization
Prota, A. E., Danel, F., Bachmann, F., Bargsten, K., Buey, R. M., Pohlmann, J., … Steinmetz, M. O. (2014). The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization. Journal of Molecular Biology, 426(8), 1848-1860. https://doi.org/10.1016/j.jmb.2014.02.005
<em>Caenorhabditis elegans</em> centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry
Hilbert, M., Erat, M. C., Hachet, V., Guichard, P., Blank, I. D., Flückiger, I., … Vakonakis, I. (2013). Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry. Proceedings of the National Academy of Sciences of the United States of America PNAS, 110(28), 11373-11378. https://doi.org/10.1073/pnas.1302721110