| First-in-human administration of [<sup>161</sup>Tb]Tb-SibuDAB and comparative dosimetry with standard [<sup>177</sup>Lu]Lu-PSMA-I&T as part of the PROGNOSTICS phase Ia study
Chirindel, A., Nicolas, G. P., Westerbergh, F., McDougall, L., Schmid, D. E., Geistlich, S., … Schibli, R. (2025). First-in-human administration of [161Tb]Tb-SibuDAB and comparative dosimetry with standard [177Lu]Lu-PSMA-I&T as part of the PROGNOSTICS phase Ia study. European Journal of Nuclear Medicine and Molecular Imaging, 52, 1628-1630. https://doi.org/10.1007/s00259-024-07009-w |
| Preclinical investigation of [<sup>149</sup>Tb]Tb-DOTATATE and [<sup>149</sup>Tb]Tb-DOTA-LM3 for tumor-targeted alpha therapy
Mapanao, A. K., Busslinger, S. D., Mehta, A., Kegler, K., Favaretto, C., Grundler, P. V., … Müller, C. (2025). Preclinical investigation of [149Tb]Tb-DOTATATE and [149Tb]Tb-DOTA-LM3 for tumor-targeted alpha therapy. European Journal of Nuclear Medicine and Molecular Imaging, 52, 1383-1398. https://doi.org/10.1007/s00259-024-07035-8 |
| Biodistribution and dosimetry of [<sup>177</sup>Lu]Lu-SibuDAB in patients with metastatic castration-resistant prostate cancer
Ritt, P., Fernández, R., Soza-Ried, C., Nicolai, H., Amaral, H., Krieger, K., … Kramer, V. (2025). Biodistribution and dosimetry of [177Lu]Lu-SibuDAB in patients with metastatic castration-resistant prostate cancer. European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-025-07102-8 |
| Preclinical comparison of (radio)lanthanides using mass spectrometry and nuclear imaging techniques: biodistribution of lanthanide-based tumor-targeting agents and lanthanides in ionic form
Wallimann, R. H., Mehta, A., Mapanao, A. K., Köster, U., Kneuer, R., Schindler, P., … Müller, C. (2025). Preclinical comparison of (radio)lanthanides using mass spectrometry and nuclear imaging techniques: biodistribution of lanthanide-based tumor-targeting agents and lanthanides in ionic form. European Journal of Nuclear Medicine and Molecular Imaging, 52, 1370-1382. https://doi.org/10.1007/s00259-024-07018-9 |
| Site-specific modification of native IgGs with flexible drug-load
Wehrmüller, J. E., Frei, J. C., Hechler, T., Kulke, M., Pahl, A., Béhé, M., … Spycher, P. R. (2025). Site-specific modification of native IgGs with flexible drug-load. ChemBioChem, 26(8), e202400511 (6 pp.). https://doi.org/10.1002/cbic.202400511 |
| Terbium-149 production: a focus on yield and quality improvement towards preclinical application
Favaretto, C., Grundler, P. V., Talip, Z., Köster, U., Johnston, K., Busslinger, S. D., … van der Meulen, N. P. (2024). Terbium-149 production: a focus on yield and quality improvement towards preclinical application. Scientific Reports, 14(1), 3284 (12 pp.). https://doi.org/10.1038/s41598-024-53610-2 |
| First-in-human administration of terbium-161-labelled somatostatin receptor subtype 2 antagonist ([<sup>161</sup>Tb]Tb-DOTA-LM3) in a patient with a metastatic neuroendocrine tumour of the ileum
Fricke, J., Westerbergh, F., McDougall, L., Favaretto, C., Christ, E., Nicolas, G. P., … Wild, D. (2024). First-in-human administration of terbium-161-labelled somatostatin receptor subtype 2 antagonist ([161Tb]Tb-DOTA-LM3) in a patient with a metastatic neuroendocrine tumour of the ileum. European Journal of Nuclear Medicine and Molecular Imaging, 51, 2517-2519. https://doi.org/10.1007/s00259-024-06641-w |
| In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [<sup>177</sup>Lu]Lu-PP-F11N in humans: the lumed phase 0b study
Rottenburger, C., Hentschel, M., Fürstner, M., McDougall, L., Kottoros, D., Kaul, F., … Wild, D. (2024). In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [177Lu]Lu-PP-F11N in humans: the lumed phase 0b study. EJNMMI Research, 14(1), 37 (13 pp.). https://doi.org/10.1186/s13550-024-01101-w |
| Targeting cancer stem cells with radioimmunotherapy: the case of the ovarian cancer stemness-associated biomarker L1CAM
Todorov, T. Z., Schibli, R., Béhé, M., & Grünberg, J. (2024). Targeting cancer stem cells with radioimmunotherapy: the case of the ovarian cancer stemness-associated biomarker L1CAM. International Journal of Translational Medicine, 4(3), 463-485. https://doi.org/10.3390/ijtm4030031 |
| Relaxed fibronectin: a potential novel target for imaging endometriotic lesions
Trachsel, B., Imobersteg, S., Valpreda, G., Singer, G., Grabherr, R., Ormos, M., … Béhé, M. (2024). Relaxed fibronectin: a potential novel target for imaging endometriotic lesions. EJNMMI Research, 14(1), 17 (11 pp.). https://doi.org/10.1186/s13550-024-01070-0 |
| Design and preclinical evaluation of a novel prostate-specific membrane antigen radioligand modified with a transthyretin binder
Vaccarin, C., Mapanao, A. K., Deberle, L. M., Becker, A. E., Borgna, F., Marzaro, G., … Müller, C. (2024). Design and preclinical evaluation of a novel prostate-specific membrane antigen radioligand modified with a transthyretin binder. Cancers, 16(7), 1262 (13 pp.). https://doi.org/10.3390/cancers16071262 |
| Liquid chromatography ICP-MS to assess the stability of <sup>175</sup>Lu- and <sup>nat</sup>Ga-based tumor-targeting agents towards the development of <sup>177</sup>Lu- and <sup>68</sup>Ga-labeled radiopharmaceuticals
Wallimann, R. H., Hensinger, H., Müller, C., Schibli, R., Kneuer, R., & Schindler, P. (2024). Liquid chromatography ICP-MS to assess the stability of 175Lu- and natGa-based tumor-targeting agents towards the development of 177Lu- and 68Ga-labeled radiopharmaceuticals. Pharmaceutics, 16(3), 299 (13 pp.). https://doi.org/10.3390/pharmaceutics16030299 |
| A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides
Beyer, D., Vaccarin, C., Deupi, X., Mapanao, A. K., Cohrs, S., Sozzi-Guo, F., … Müller, C. (2023). A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides. EJNMMI Research, 13(1), 32 (14 pp.). https://doi.org/10.1186/s13550-023-00979-2 |
| Investigations using albumin binders to modify the tissue distribution profile of radiopharmaceuticals exemplified with folate radioconjugates
Busslinger, S. D., Becker, A. E., Vaccarin, C., Deberle, L. M., Renz, M. L., Groehn, V., … Müller, C. (2023). Investigations using albumin binders to modify the tissue distribution profile of radiopharmaceuticals exemplified with folate radioconjugates. Cancers, 15(17), 4259 (19 pp.). https://doi.org/10.3390/cancers15174259 |
| <sup>161</sup>Tb-DOTATOC production using a fully automated disposable cassette system: a first step toward the introduction of <sup>161</sup>Tb into the clinic
Favaretto, C., Grundler, P. V., Talip, Z., Landolt, S., Sepini, L., Köster, U., … van der Meulen, N. P. (2023). 161Tb-DOTATOC production using a fully automated disposable cassette system: a first step toward the introduction of 161Tb into the clinic. Journal of Nuclear Medicine, 64(7), 1138-1144. https://doi.org/10.2967/jnumed.122.265268 |
| Targeting mTORC1 activity to improve efficacy of radioligand therapy in cancer
Grzmil, M., Wiesmann, F., Schibli, R., & Behe, M. (2023). Targeting mTORC1 activity to improve efficacy of radioligand therapy in cancer. Cancers, 15(1), 17 (12 pp.). https://doi.org/10.3390/cancers15010017 |
| Detecting radio- and chemoresistant cells in 3D cancer co-cultures using chromatin biomarkers
Pekeč, T., Venkatachalapathy, S., Shim, A. R., Paysan, D., Grzmil, M., Schibli, R., … Shivashankar, G. V. (2023). Detecting radio- and chemoresistant cells in 3D cancer co-cultures using chromatin biomarkers. Scientific Reports, 13(1), 20662 (14 pp.). https://doi.org/10.1038/s41598-023-47287-2 |
| Signaling network response to <em>α</em>-particle–targeted therapy with the <sup>225</sup>Ac-labeled minigastrin analog <sup>225</sup>Ac-PP-F11N reveals the radiosensitizing potential of histone deacetylase inhibitors
Qin, Y., Imobersteg, S., Frank, S., Blanc, A., Chiorazzo, T., Berger, P., … Grzmil, M. (2023). Signaling network response to α-particle–targeted therapy with the 225Ac-labeled minigastrin analog 225Ac-PP-F11N reveals the radiosensitizing potential of histone deacetylase inhibitors. Journal of Nuclear Medicine, 64(6), 873-879. https://doi.org/10.2967/jnumed.122.264597 |
| Reducing kidney uptake of radiolabelled exendin-4 using variants of the renally cleavable linker MVK
Trachsel, B., Valpreda, G., Lutz, A., Schibli, R., Mu, L., & Béhé, M. (2023). Reducing kidney uptake of radiolabelled exendin-4 using variants of the renally cleavable linker MVK. EJNMMI Radiopharmacy and Chemistry, 8(1), 21 (11 pp.). https://doi.org/10.1186/s41181-023-00206-2 |
| Albumin-binding and conventional PSMA ligands in combination with <sup>161</sup>Tb: biodistribution, dosimetry, and preclinical therapy
Tschan, V. J., Busslinger, S. D., Bernhardt, P., Grundler, P. V., Zeevaart, J. R., Köster, U., … Müller, C. (2023). Albumin-binding and conventional PSMA ligands in combination with 161Tb: biodistribution, dosimetry, and preclinical therapy. Journal of Nuclear Medicine, 64(10), 1625-1631. https://doi.org/10.2967/jnumed.123.265524 |