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Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
Mayer, D., Damberger, F. F., Samarasimhareddy, M., Feldmueller, M., Vuckovic, Z., Flock, T., … Veprintsev, D. B. (2019). Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation. Nature Communications, 10, 1261 (14 pp.). https://doi.org/10.1038/s41467-019-09204-y
An online resource for GPCR structure determination and analysis
Munk, C., Mutt, E., Isberg, V., Nikolajsen, L. F., Bibbe, J. M., Flock, T., … Gloriam, D. E. (2019). An online resource for GPCR structure determination and analysis. Nature Methods, 16(2), 151-162. https://doi.org/10.1038/s41592-018-0302-x
Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit
Tsai, C. J., Marino, J., Adaixo, R., Pamula, F., Muehle, J., Maeda, S., … Schertler, G. (2019). Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit. eLife, 8, e46041 (19 pp.). https://doi.org/10.7554/eLife.46041
Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish
Gerrard, E., Mutt, E., Nagata, T., Koyanagi, M., Flock, T., Lesca, E., … Lucas, R. J. (2018). Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish. Proceedings of the National Academy of Sciences of the United States of America PNAS, 115(24), 6201-6206. https://doi.org/10.1073/pnas.1721333115
Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas
Kayikci, M., Venkatakrishnan, A. J., Scott-Brown, J., Ravarani, C. N. J., Flock, T., & Babu, M. M. (2018). Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas. Nature Structural and Molecular Biology, 25(2), 185-194. https://doi.org/10.1038/s41594-017-0019-z
Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation
Sente, A., Peer, R., Srivastava, A., Baidya, M., Lesk, A. M., Balaji, S., … Flock, T. (2018). Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation. Nature Structural and Molecular Biology, 25(6), 538-545. https://doi.org/10.1038/s41594-018-0071-3
Crystal structure of rhodopsin in complex with a mini-G<sub>o</sub> sheds light on the principles of G protein selectivity
Tsai, C. J., Pamula, F., Nehmé, R., Mühle, J., Weinert, T., Flock, T., … Schertler, G. F. X. (2018). Crystal structure of rhodopsin in complex with a mini-Go sheds light on the principles of G protein selectivity. Science Advances, 4(9), aat7052 (9 pp.). https://doi.org/10.1126/sciadv.aat7052